Anti-E-Cadherin Antibody (CAB3149)
- SKU:
- CAB3149
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Mouse
- Isotype:
- IgG1
- Synonyms:
- CDH1
- Synonyms:
- CD324
- Synonyms:
- CDHE
- Synonyms:
- LCAM
- Synonyms:
- UVO
- Synonyms:
- AA960649
- Synonyms:
- E-cad
- Synonyms:
- L-CAM
- Synonyms:
- Um
- Synonyms:
- cadherin-1
Description
| Product Name: | E-Cadherin mouse mAb |
| Product Code: | CAB3149 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO, AA960649, ARC-1, E-cad, Ecad, L-CAM, Um, cadherin-1 |
| Applications: | WB, IHC, FC |
| Reactivity: | Human, Mouse |
| Host Species: | Mouse |
| Immunogen: | Recombinant protein of mouse E-Cadherin. |
| Applications: | WB, IHC, FC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 FC 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Immunogen: | Recombinant protein of mouse E-Cadherin. |
| Purification Method: | Protein A purified |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.05% sodium azide, 0.2% BSA, 40% glycerol, pH7.4. |
| Isotype: | IgG1 |
| Sequence: | Email for sequence |
| Gene ID: | 12550 |
| Uniprot: | P09803 |
| Calculated MW: | 98kDa |
| Observed MW: | Refer to figures |
| UniProt Protein Function: | CDH1: a single-pass type I membrane protein, and calcium dependent cell adhesion proteins. It is a ligand for integrin alpha-E/beta-7, and it colocalizes with DLG7 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Defects in CDH1 are involved in dysfunction of the cell-cell adhesion system, triggering cancer invasion (gastric, breast, ovary, endometrium and thyroid) and metastasis. Has a potent invasive suppressor role. |
| UniProt Protein Details: | Protein type:Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, integral; Ubiquitin ligase Cellular Component: apical junction complex; Golgi apparatus; internal side of plasma membrane; cell surface; focal adhesion; basolateral plasma membrane; lateral loop; integral to membrane; catenin complex; trans-Golgi network; intercellular junction; actin cytoskeleton; cell-cell adherens junction; adherens junction; membrane; apical part of cell; perinuclear region of cytoplasm; axon; cytoplasm; plasma membrane; nerve terminal; cell junction; endosome; lateral plasma membrane Molecular Function:protein domain specific binding; protein binding; gamma-catenin binding; metal ion binding; beta-catenin binding; GTPase activating protein binding; calcium ion binding; ankyrin binding; cell adhesion molecule binding; glycoprotein binding; protein phosphatase binding Biological Process: in utero embryonic development; positive regulation of transcription, DNA-dependent; regulation of caspase activity; regulation of epithelial cell proliferation; trophectodermal cell differentiation; regulation of water loss via skin; cell-cell adhesion; sensory perception of sound; regulation of protein localization; synaptogenesis; protein metabolic process; calcium-dependent cell-cell adhesion; positive regulation of transcription factor import into nucleus; negative regulation of cell-cell adhesion; cell adhesion; homophilic cell adhesion; protein homooligomerization; negative regulation of epithelial cell proliferation |
| UniProt Code: | P09803 |
| NCBI GenInfo Identifier: | 115419 |
| NCBI Gene ID: | 12550 |
| NCBI Accession: | P09803.1 |
| UniProt Secondary Accession: | P09803,Q61377, |
| UniProt Related Accession: | P09803 |
| Molecular Weight: | 884 |
| NCBI Full Name: | Cadherin-1 |
| NCBI Synonym Full Names: | cadherin 1 |
| NCBI Official Symbol: | Cdh1 |
| NCBI Official Synonym Symbols: | Um; UVO; Ecad; E-cad; L-CAM; AA960649 |
| NCBI Protein Information: | cadherin-1; ARC-1; E-cadherin; uvomorulin; epithelial cadherin |
| UniProt Protein Name: | Cadherin-1 |
| UniProt Synonym Protein Names: | ARC-1; Epithelial cadherin; E-cadherin; Uvomorulin; CD_antigen: CD324Cleaved into the following 3 chains:E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3 |
| Protein Family: | Cadherin |
| UniProt Gene Name: | Cdh1 |
| UniProt Entry Name: | CADH1_MOUSE |
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