Signal Transduction Antibodies 3

Anti-DZIP3 Antibody (CAB7179)

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SKU:
CAB7179
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-DZIP3 Antibody
Antibody SKU:CAB7179
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human DZIP3 (NP_055463.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:293T
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human DZIP3 (NP_055463.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MDSL PDEF FVRH PAVE DQRK EETE NKLE KSSG QLNK QEND IPTD LVPV NLLL EVKK LLNA INTL PKGV VPHI KKFL QEDF SFQT MQRE VAAN SQNG EEIV PALT LRFL ITQL EAAL RNIQ AGNY TAHQ INIG YYLT LLFL YGVA LTER GKKE DYTE AENK FLVM KMMI QENE ICEN FMSL VYFG RGLL RCAQ KRYN GGLL EFHK SLQE IGDK NDHW FDID PTED EDLP TT
Gene ID:9666
Uniprot:Q86Y13
Cellular Location:Cytoplasm
Calculated MW:35kDa/138kDa
Observed MW:138kDa
Synonyms:DZIP3, PPP1R66, UURF2, hRUL138
Background:
UniProt Protein Function:DZIP3: E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Able to specifically bind RNA. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 6.3.2.-; EC 6.3.2.19; RNA-binding; Ubiquitin conjugating system; Ubiquitin ligase; Ligase

Chromosomal Location of Human Ortholog: 3q13.13

Cellular Component: cytoplasm

Molecular Function:ligase activity; phosphatase binding; polyubiquitin binding; protein binding; RNA binding; ubiquitin-protein ligase activity; zinc ion binding

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process

UniProt Code:Q86Y13
NCBI GenInfo Identifier:50400482
NCBI Gene ID:9666
NCBI Accession:Q86Y13.2
UniProt Secondary Accession:Q86Y13,O75162, Q6P3R9, Q6PH82, Q86Y14, Q86Y15, Q86Y16 Q8IWI0, Q96RS9, B3KN01,
UniProt Related Accession:Q86Y13
Molecular Weight:35,240 Da
NCBI Full Name:E3 ubiquitin-protein ligase DZIP3
NCBI Synonym Full Names:DAZ interacting zinc finger protein 3
NCBI Official Symbol:DZIP3  
NCBI Official Synonym Symbols:UURF2; PPP1R66; hRUL138  
NCBI Protein Information:E3 ubiquitin-protein ligase DZIP3
UniProt Protein Name:E3 ubiquitin-protein ligase DZIP3
UniProt Synonym Protein Names:DAZ-interacting protein 3; RNA-binding ubiquitin ligase of 138 kDa; hRUL138
Protein Family:E3 ubiquitin-protein ligase
UniProt Gene Name:DZIP3  
UniProt Entry Name:DZIP3_HUMAN
Anti-DZIP3 Antibody (CAB7179)Western blot analysis of extracts of 293T cells, using DZIP3 Antibody (CAB7179) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s.
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