Immunology Antibodies 1

Anti-DYRK1A Antibody (CAB0595)

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SKU:
CAB0595
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-DYRK1A Antibody
Antibody SKU:CAB0595
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 624-763 of human DYRK1A (NP_001387.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:1000
Reactivity:Human, Mouse, Rat
Positive Samples:NCI-H460, 293T, K-562, HeLa, Jurkat, Mouse brain, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 624-763 of human DYRK1A (NP_001387.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LGNR TRPR VYNS PTNS SSTQ DSME VGHS HHSM TSLS SSTT SSST SSSS TGNQ GNQA YQNR PVAA NTLD FGQN GAMD VNLT VYSN PRQE TGIA GHPT YQFS ANTG PAHY MTEG HLTM RQGA DREE SPMT GVCV QQSP VASS
Gene ID:1859
Uniprot:Q13627
Cellular Location:Nucleus speckle
Calculated MW:60kDa/61kDa/66kDa/84kDa/85kDa
Observed MW:72kDa
Synonyms:DYRK1A, DYRK, DYRK1, HP86, MNB, MNBH, MRD7
Background:This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.
UniProt Protein Function:DYRK1A: a dual-specificity protein kinase of the DYRK family. Contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. May play a significant role in a pathway regulating cell proliferation and may be involved in brain development. Its gene is localized in the Down syndrome (DS) critical region of chromosome 21, and is a strong candidate gene for learning defects associated with Down syndrome. Overexpression in mice gives rise to neurological abnormalities similar to those observed in DS. Five splice-variant isoforms have been described.
UniProt Protein Details:

Protein type:Protein kinase, dual-specificity (non-receptor); Protein kinase, CMGC; Kinase, protein; EC 2.7.12.2; CMGC group; DYRK family; Dyrk1 subfamily

Chromosomal Location of Human Ortholog: 21q22.13

Cellular Component: nuclear speck; nucleoplasm; nucleus

Molecular Function:non-membrane spanning protein tyrosine kinase activity; protein binding; protein kinase activity; protein self-association; protein serine/threonine kinase activity; protein-tyrosine kinase activity; tau protein binding

Biological Process: circadian rhythm; negative regulation of DNA damage response, signal transduction by p53 class mediator; nervous system development; peptidyl-threonine phosphorylation; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; protein amino acid phosphorylation

Disease: Mental Retardation, Autosomal Dominant 7

NCBI Summary:This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008]
UniProt Code:Q13627
NCBI GenInfo Identifier:3219996
NCBI Gene ID:1859
NCBI Accession:Q13627.2
UniProt Secondary Accession:Q13627,O60769, Q92582, Q92810, Q9UNM5,
UniProt Related Accession:Q13627
Molecular Weight:66,099 Da
NCBI Full Name:Dual specificity tyrosine-phosphorylation-regulated kinase 1A
NCBI Synonym Full Names:dual specificity tyrosine phosphorylation regulated kinase 1A
NCBI Official Symbol:DYRK1A  
NCBI Official Synonym Symbols:MNB; DYRK; HP86; MNBH; MRD7; DYRK1  
NCBI Protein Information:dual specificity tyrosine-phosphorylation-regulated kinase 1A
UniProt Protein Name:Dual specificity tyrosine-phosphorylation-regulated kinase 1A
UniProt Synonym Protein Names:Dual specificity YAK1-related kinase; HP86; Protein kinase minibrain homolog; MNBH; hMNB
Protein Family:Dual specificity tyrosine-phosphorylation-regulated kinase
UniProt Gene Name:DYRK1A  
UniProt Entry Name:DYR1A_HUMAN
Anti-DYRK1A Antibody (CAB0595)Western blot analysis of extracts of various cell lines, using DYRK1A antibody (CAB0595) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
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