Signal Transduction Antibodies 2

Anti-DYNLRB1 Antibody (CAB15197)

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SKU:
CAB15197
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-DYNLRB1 Antibody
Antibody SKU:CAB15197
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-63 of human DYNLRB1 (NP_001268656.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:293T, Mouse brain
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-63 of human DYNLRB1 (NP_001268656.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MDNP TTTQ YASL MHSF ILKA RSTV RDID PQND LTFL RIRS KKNE IMVA PDKD YFLI VIQN PTE
Gene ID:83658
Uniprot:Q9NP97
Cellular Location:Cytoplasm, cytoskeleton
Calculated MW:5kDa/10kDa
Observed MW:20kDa
Synonyms:DYNLRB1, BITH, BLP, DNCL2A, DNLC2A, ROBLD1
Background:This gene is a member of the roadblock dynein light chain family. The encoded cytoplasmic protein is capable of binding intermediate chain proteins, interacts with transforming growth factor-beta, and has been implicated in the regulation of actin modulating proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 12 and 18.
UniProt Protein Function:DYNLRB1: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Belongs to the GAMAD family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 20q11.22

Cellular Component: centrosome; cilium; cytoplasm; cytoplasmic dynein complex; membrane

Molecular Function:dynein intermediate chain binding; protein binding

Biological Process: microtubule-based movement; visual behavior

NCBI Summary:This gene is a member of the roadblock dynein light chain family. The encoded cytoplasmic protein is capable of binding intermediate chain proteins, interacts with transforming growth factor-beta, and has been implicated in the regulation of actin modulating proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 12 and 18. [provided by RefSeq, Aug 2013]
UniProt Code:Q9NP97
NCBI GenInfo Identifier:528524492
NCBI Gene ID:83658
NCBI Accession:NP_001268656.1
UniProt Secondary Accession:Q9NP97,Q5TC72, Q96IV3, Q9NQM2, B1AKR5,
UniProt Related Accession:Q9NP97
Molecular Weight:26.71kD
NCBI Full Name:dynein light chain roadblock-type 1 isoform b
NCBI Synonym Full Names:dynein light chain roadblock-type 1
NCBI Official Symbol:DYNLRB1  
NCBI Official Synonym Symbols:BLP; BITH; DNCL2A; DNLC2A; ROBLD1  
NCBI Protein Information:dynein light chain roadblock-type 1
UniProt Protein Name:Dynein light chain roadblock-type 1
UniProt Synonym Protein Names:Bithoraxoid-like protein; BLP; Dynein light chain 2A, cytoplasmic; Dynein-associated protein Km23; Roadblock domain-containing protein 1
Protein Family:Dynein
UniProt Gene Name:DYNLRB1  
Anti-DYNLRB1 Antibody (CAB15197)Western blot analysis of extracts of various cell lines, using DYNLRB1 antibody (CAB15197) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-DYNLRB1 Antibody (CAB15197)Immunohistochemistry of paraffin-embedded Human thyroid cancer using DYNLRB1 Rabbit pAb (CAB15197) at dilution of 1:100 (40x lens).
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