Signal Transduction Antibodies 1
Anti-DYNLL2 Antibody (CAB13889)
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- SKU:
- CAB13889
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-DYNLL2 Antibody |
| Antibody SKU: | CAB13889 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-89 of human DYNLL2 (NP_542408.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse brain, Mouse kidney, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-89 of human DYNLL2 (NP_542408.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSDR KAVI KNAD MSED MQQD AVDC ATQA MEKY NIEK DIAA YIKK EFDK KYNP TWHC IVGR NFGS YVTH ETKH FIYF YLGQ VAIL LFKS G |
| Gene ID: | 140735 |
| Uniprot: | Q96FJ2 |
| Cellular Location: | Cytoplasm, cytoskeleton |
| Calculated MW: | 10kDa |
| Observed MW: | 13kDa |
| Synonyms: | DYNLL2, DNCL1B, Dlc2, RSPH22 |
| Background: |
| UniProt Protein Function: | DYNLL2: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Belongs to the dynein light chain family. |
| UniProt Protein Details: | Protein type:Microtubule-binding; Motility/polarity/chemotaxis; Motor Chromosomal Location of Human Ortholog: 17q22 Cellular Component: dynein complex; microtubule; centrosome; membrane; plasma membrane; myosin complex; cytosol; nucleus Molecular Function:protein binding; cytoskeletal protein binding; motor activity Biological Process: metabolic process; transport; apoptosis; organelle organization and biogenesis; antigen processing and presentation of exogenous peptide antigen via MHC class II; microtubule-based process; synaptic target recognition |
| UniProt Code: | Q96FJ2 |
| NCBI GenInfo Identifier: | 56748850 |
| NCBI Gene ID: | 140735 |
| NCBI Accession: | Q96FJ2.1 |
| UniProt Secondary Accession: | Q96FJ2,B2R5B4, |
| UniProt Related Accession: | Q96FJ2 |
| Molecular Weight: | 10,350 Da |
| NCBI Full Name: | Dynein light chain 2, cytoplasmic |
| NCBI Synonym Full Names: | dynein, light chain, LC8-type 2 |
| NCBI Official Symbol: | DYNLL2 |
| NCBI Official Synonym Symbols: | Dlc2; DNCL1B; RSPH22 |
| NCBI Protein Information: | dynein light chain 2, cytoplasmic; 8 kDa dynein light chain b; DLC8b; radial spoke 22 homolog |
| UniProt Protein Name: | Dynein light chain 2, cytoplasmic |
| UniProt Synonym Protein Names: | 8 kDa dynein light chain b; DLC8b; Dynein light chain LC8-type 2 |
| Protein Family: | Dynein |
| UniProt Gene Name: | DYNLL2 |
| UniProt Entry Name: | DYL2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using DYNLL2 antibody (CAB13889) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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