| UniProt Protein Function: | DNCLI2: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Belongs to the dynein light intermediate chain family. Protein type: Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 16q22.1 Cellular Component: centrosome; microtubule; membrane; cytoplasmic dynein complex; cytosol Molecular Function: microtubule motor activity; ATP binding Biological Process: centrosome localization; transport; metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class II; microtubule cytoskeleton organization and biogenesis; microtubule-based movement |
| UniProt Protein Details: | |
| NCBI Summary: | Cytoplasmic dynein is a microtubule-associated motor protein (Hughes et al., 1995 [PubMed 7738094]). See DYNC1H1 (MIM 600112) for general information about dyneins.[supplied by OMIM, Mar 2008] |
| UniProt Code: | O43237 |
| NCBI GenInfo Identifier: | 5453634 |
| NCBI Gene ID: | 1783 |
| NCBI Accession: | NP_006132.1 |
| UniProt Secondary Accession: | O43237,Q8TAT3, A8K6V1, B4DZP4 |
| UniProt Related Accession: | O43237 |
| Molecular Weight: | 45,005 Da |
| NCBI Full Name: | cytoplasmic dynein 1 light intermediate chain 2 isoform 1 |
| NCBI Synonym Full Names: | dynein, cytoplasmic 1, light intermediate chain 2 |
| NCBI Official Symbol: | DYNC1LI2 |
| NCBI Official Synonym Symbols: | LIC2; DNCLI2 |
| NCBI Protein Information: | cytoplasmic dynein 1 light intermediate chain 2; LIC-2; LIC53/55; dynein light intermediate chain 2, cytosolic; dynein, cytoplasmic, light intermediate polypeptide 2 |
| UniProt Protein Name: | Cytoplasmic dynein 1 light intermediate chain 2 |
| UniProt Synonym Protein Names: | Dynein light intermediate chain 2, cytosolic; LIC-2; LIC53/55 |
| Protein Family: | Cytoplasmic dynein |
| UniProt Gene Name: | DYNC1LI2 |
| UniProt Entry Name: | DC1L2_HUMAN |
