Signal Transduction Antibodies 2
Anti-DYNC1I1 Antibody (CAB3833)
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- SKU:
- CAB3833
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-DYNC1I1 Antibody |
| Antibody SKU: | CAB3833 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human DYNC1I1 (NP_001129028.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:200 - 1:2000 IHC 1:20 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Jurkat, SH-SY5Y, HeLa, Mouse testis, Mouse brain, Mouse skeletal muscle, Rat brain, Rat testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human DYNC1I1 (NP_001129028.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSDK SDLK AELE RKKQ RLAQ IREE KKRK EEER KKKE ADMQ QKKE PVQD DSDL DRKR RETE ALLQ SIGI SPEP PLVP TPMS PSSK SVST PSEA GSQD SGDL GPLT RTLQ WDTD PSVL QLQS DSEL GRRL HKLG VSKV TQVD FLPR EVVS YSKE TQTP LATH QSEE DEED EEMV ESKV GQDS ELEN QDKK QEVK EAPP RELT EEEK QQIL HSEE FLIF FDRT |
| Gene ID: | 1780 |
| Uniprot: | O14576 |
| Cellular Location: | Chromosome, Cytoplasm, centromere, cytoskeleton, kinetochore, spindle pole |
| Calculated MW: | 67kDa/68kDa/70kDa/72kDa |
| Observed MW: | 73kDa |
| Synonyms: | DYNC1I1, DNCI1, DNCIC1 |
| Background: |
| UniProt Protein Function: | DYNC1I1: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150- glued) DCNT1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores. Belongs to the dynein intermediate chain family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Microtubule-binding; Motor; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 7q21.3 Cellular Component: kinetochore; spindle pole; microtubule; recycling endosome; cytoplasmic dynein complex; perinuclear region of cytoplasm; cytosol; vesicle Molecular Function:protein binding; spectrin binding; microtubule binding; motor activity; microtubule motor activity Biological Process: metabolic process; vesicle transport along microtubule; antigen processing and presentation of exogenous peptide antigen via MHC class II |
| UniProt Code: | O14576 |
| NCBI GenInfo Identifier: | 6647481 |
| NCBI Gene ID: | 1780 |
| NCBI Accession: | O14576.2 |
| UniProt Related Accession: | O14576 |
| Molecular Weight: | Observed Molecular Weight: (Observed)72kD.Predicted Molecular Weight: (Calculated)73kDa. |
| NCBI Full Name: | Cytoplasmic dynein 1 intermediate chain 1 |
| NCBI Synonym Full Names: | dynein cytoplasmic 1 intermediate chain 1 |
| NCBI Official Symbol: | DYNC1I1 |
| NCBI Official Synonym Symbols: | DNCI1; DNCIC1 |
| NCBI Protein Information: | cytoplasmic dynein 1 intermediate chain 1 |
| UniProt Protein Name: | Cytoplasmic dynein 1 intermediate chain 1 |
| UniProt Synonym Protein Names: | Cytoplasmic dynein intermediate chain 1; Dynein intermediate chain 1, cytosolic; DH IC-1 |
| Protein Family: | Cytoplasmic dynein |
| UniProt Gene Name: | DYNC1I1 |
| UniProt Entry Name: | DC1I1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using DYNC1I1 antibody (CAB3833) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
 | Immunohistochemistry of paraffin-embedded human stomach using DYNC1I1 antibody (CAB3833) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded rat brain using DYNC1I1 antibody (CAB3833) at dilution of 1:100 (40x lens). |
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