Anti-DVL3 Antibody (CAB3842)
- SKU:
- CAB3842
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- DVL3
- Synonyms:
- DRS3
Description
| Product Name: | DVL3 Rabbit pAb |
| Product Code: | CAB3842 |
| Size: | 100uL |
| Synonyms: | DVL3, DRS3 |
| Applications: | WB, IHC, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human DVL3 |
| Applications: | WB, IHC, IF |
| Recommended Dilutions: | WB 1:500 - 1:1000 IHC 1:50 - 1:100 IF 1:20 - 1:50 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | NIH/3T3, C6, Mouse brain |
| Immunogen: | A synthetic peptide of human DVL3 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 1857 |
| Uniprot: | Q92997 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 76kDa/78kDa |
| Observed MW: | 93KDa |
| UniProt Protein Function: | DVL3: a protein in the WNT/planar cell polarity (PCP) signaling pathway. Dvl2-deficient mice indicate that Dvl2 is essential for normal cardiac morphogenesis, somite segmentation and neural tube closure. Transduces the Wnt signal by interacting with the cytoplasmic Axin complex. Dvl and Axin each contain a DIX domains, which mediate their dynamic polymerization. The Dvl-Axin interaction is essential for Wnt signaling. Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2. Interacts with Dixin and Rac. There is functional redundancy between Dvl1 and Dvl2 in some phenotypes. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 3q27 Cellular Component: cytosol Molecular Function:protein binding; protease binding; frizzled binding; protein heterodimerization activity; beta-catenin binding; receptor binding Biological Process: response to drug; positive regulation of JNK activity; Wnt receptor signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway; positive regulation of transcription, DNA-dependent; positive regulation of protein amino acid phosphorylation; Wnt receptor signaling pathway through beta-catenin |
| NCBI Summary: | This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q92997 |
| NCBI GenInfo Identifier: | 6919875 |
| NCBI Gene ID: | 1857 |
| NCBI Accession: | Q92997.2 |
| UniProt Secondary Accession: | Q92997,O14642, Q13531, Q8N5E9, Q92607, B4E3E5, D3DNT0 |
| UniProt Related Accession: | Q92997 |
| Molecular Weight: | 716 |
| NCBI Full Name: | Segment polarity protein dishevelled homolog DVL-3 |
| NCBI Synonym Full Names: | dishevelled segment polarity protein 3 |
| NCBI Official Symbol: | DVL3 |
| NCBI Protein Information: | segment polarity protein dishevelled homolog DVL-3; DSH homolog 3; dishevelled-3; dishevelled, dsh homolog 3; dishevelled 3 (homologous to Drosophila dsh) |
| UniProt Protein Name: | Segment polarity protein dishevelled homolog DVL-3 |
| UniProt Synonym Protein Names: | DSH homolog 3 |
| Protein Family: | Segment polarity protein dishevelled |
| UniProt Gene Name: | DVL3 |
| UniProt Entry Name: | DVL3_HUMAN |
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