Metabolism Antibodies 2

Anti-DVL2 Antibody (CAB7551)

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SKU:
CAB7551
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism

Description

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Antibody Name:Anti-DVL2 Antibody
Antibody SKU:CAB7551
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-340 of human DVL2 (NP_004413.1).
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, Mouse thymus, Mouse brain, Mouse kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-340 of human DVL2 (NP_004413.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAGS STGG GGVG ETKV IYHL DEEE TPYL VKIP VPAE RITL GDFK SVLQ RPAG AKYF FKSM DQDF GVVK EEIS DDNA RLPC FNGR VVSW LVSS DNPQ PEMA PPVH EPRA ELAP PAPP LPPL PPER TSGI GDSR PPSF HPNV SSSH ENLE PETE TESV VSLR RERP RRRD SSEH GAGG HRTG GPSR LERH LAGY ESSS TLMT SELE STSL GDSD EEDT MSRF SSST EQSS ASRL LKRH RRRR KQRP PRLE RTSS FSSV TDST MSLN IITV TLNM EKYN FLGI SIVG QSNE RGDG GIYI GSIM KGGA VAAD GRIE PGDM LLQV NDMN FENM SNDD AVRV LRDI
Gene ID:1856
Uniprot:O14641
Cellular Location:Cell membrane, Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle, Peripheral membrane protein, cytosol
Calculated MW:78kDa
Observed MW:95kDa
Synonyms:DVL2
Background:This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.
UniProt Protein Function:DVL2: a protein in the WNT/planar cell polarity (PCP) signaling pathway. Dvl2-deficient mice indicate that Dvl2 is essential for normal cardiac morphogenesis, somite segmentation and neural tube closure. Transduces the Wnt signal by interacting with the cytoplasmic Axin complex. Dvl and Axin each contain a DIX domains, which mediate their dynamic polymerization. The Dvl-Axin interaction is essential for Wnt signaling. Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2. Interacts with Dixin and Rac. There is functional redundancy between Dvl1 and Dvl2 in some phenotypes.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: clathrin-coated endocytic vesicle; cytoplasm; cytoplasmic vesicle; cytosol; nucleus

Molecular Function:frizzled binding; identical protein binding; protein binding

Biological Process: heart development; neural tube closure; positive regulation of JNK activity; positive regulation of protein amino acid phosphorylation; positive regulation of transcription factor activity; positive regulation of transcription, DNA-dependent; segment specification; transcription from RNA polymerase II promoter; Wnt receptor signaling pathway; Wnt receptor signaling pathway through beta-catenin; Wnt receptor signaling pathway, planar cell polarity pathway

NCBI Summary:This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008]
UniProt Code:O14641
NCBI GenInfo Identifier:6919871
NCBI Gene ID:1856
NCBI Accession:O14641.1
UniProt Secondary Accession:O14641,Q53XM0, D3DTN3,
UniProt Related Accession:O14641
Molecular Weight:78,948 Da
NCBI Full Name:Segment polarity protein dishevelled homolog DVL-2
NCBI Synonym Full Names:dishevelled segment polarity protein 2
NCBI Official Symbol:DVL2  
NCBI Protein Information:segment polarity protein dishevelled homolog DVL-2
UniProt Protein Name:Segment polarity protein dishevelled homolog DVL-2
UniProt Synonym Protein Names:DSH homolog 2
Protein Family:Segment polarity protein dishevelled
UniProt Gene Name:DVL2  
UniProt Entry Name:DVL2_HUMAN
Anti-DVL2 Antibody (CAB7551)Western blot analysis of extracts of various cell lines, using DVL2 Antibody (CAB7551) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
Anti-DVL2 Antibody (CAB7551)Immunohistochemistry of paraffin-embedded rat heart using DVL2 antibody (CAB7551) at dilution of 1:100 (40x lens).
Anti-DVL2 Antibody (CAB7551)Immunohistochemistry of paraffin-embedded human gastric cancer using DVL2 antibody (CAB7551) at dilution of 1:100 (40x lens).
Anti-DVL2 Antibody (CAB7551)Immunohistochemistry of paraffin-embedded mouse heart using DVL2 antibody (CAB7551) at dilution of 1:100 (40x lens).
Anti-DVL2 Antibody (CAB7551)Immunofluorescence analysis of NIH/3T3 cells using DVL2 antibody (CAB7551) at dilution of 1:100. Blue: DAPI for nuclear staining.
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