Cell Biology Antibodies 9

Anti-DUSP9 Antibody (CAB3839)

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SKU:
CAB3839
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-DUSP9 Antibody
Antibody SKU:CAB3839
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant protein of human DUSP9
Application:WB IHC IF
Recommended Dilution:WB 1:200 - 1:2000 IHC 1:20 - 1:200 IF 1:20 - 1:100
Reactivity:Human, Mouse
Positive Samples:HeLa, HepG2, Mouse liver
Immunogen:Recombinant protein of human DUSP9
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:1852
Uniprot:Q99956
Cellular Location:Cytoplasm
Calculated MW:41kDa
Observed MW:41kDa
Synonyms:DUSP9, MKP-4, MKP4
Background:The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases and is localized to the cytoplasm and nucleus. Aberrant expression of this gene is associated with type 2 diabetes and cancer progression in several cell types. Alternate splicing results in multiple transcript variants.
UniProt Protein Function:DUSP9: a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (ERK, JNK, p38). Shows selectivity for members of the ERK family, is expressed at high levels in placenta, kidney, and fetal liver, and is localized to the cytoplasm and nucleus.
UniProt Protein Details:

Protein type:Protein phosphatase, dual-specificity; Motility/polarity/chemotaxis; EC 3.1.3.48; EC 3.1.3.16

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: cytoplasm; nucleus

Molecular Function:protein binding; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; phosphoprotein phosphatase activity

Biological Process: JNK cascade; protein amino acid dephosphorylation; inactivation of MAPK activity

NCBI Summary:The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases, is expressed only in placenta, kidney, and fetal liver, and is localized to the cytoplasm and nucleus. [provided by RefSeq, Jul 2008]
UniProt Code:Q99956
NCBI GenInfo Identifier:3913541
NCBI Gene ID:1852
NCBI Accession:Q99956.1
UniProt Secondary Accession:Q99956,D3DWU5,
UniProt Related Accession:Q99956
Molecular Weight:384
NCBI Full Name:Dual specificity protein phosphatase 9
NCBI Synonym Full Names:dual specificity phosphatase 9
NCBI Official Symbol:DUSP9  
NCBI Official Synonym Symbols:MKP4; MKP-4  
NCBI Protein Information:dual specificity protein phosphatase 9; map kinase phosphatase 4; serine/threonine specific protein phosphatase; mitogen-activated protein kinase phosphatase 4
UniProt Protein Name:Dual specificity protein phosphatase 9
UniProt Synonym Protein Names:Mitogen-activated protein kinase phosphatase 4; MAP kinase phosphatase 4; MKP-4
Protein Family:Dual specificity protein phosphatase
UniProt Gene Name:DUSP9  
UniProt Entry Name:DUS9_HUMAN
Anti-DUSP9 Antibody (CAB3839)Western blot analysis of extracts of various cell lines, using DUSP9 antibody (CAB3839) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
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