Cell Biology Antibodies 7
Anti-DUSP2 Antibody (CAB16366)
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- SKU:
- CAB16366
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-DUSP2 Antibody |
| Antibody SKU: | CAB16366 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 150-250 of human DUSP2 (NP_004409.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, NIH/3T3, HeLa, MCF7 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 150-250 of human DUSP2 (NP_004409.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ALPP TGDK TSRS DSRA PVYD QGGP VEIL PYLF LGSC SHSS DLQG LQAC GITA VLNV SASC PNHF EGLF RYKS IPVE DNQM VEIS AWFQ EAIG FIDW VKNS G |
| Gene ID: | 1844 |
| Uniprot: | Q05923 |
| Cellular Location: | Nucleus |
| Calculated MW: | 34kDa |
| Observed MW: | 34kDa |
| Synonyms: | DUSP2, PAC-1, PAC1 |
| Background: | The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in the nucleus. |
| UniProt Code: | Q05923 |
| NCBI GenInfo Identifier: | 4758206 |
| NCBI Gene ID: | 1844 |
| NCBI Accession: | NP_004409 |
| UniProt Secondary Accession: | Q05923,Q53T45, |
| UniProt Related Accession: | Q05923 |
| Molecular Weight: | 34,400 Da |
| NCBI Full Name: | dual specificity protein phosphatase 2 |
| NCBI Synonym Full Names: | dual specificity phosphatase 2 |
| NCBI Official Symbol: | DUSP2 |
| NCBI Official Synonym Symbols: | PAC1; PAC-1 |
| NCBI Protein Information: | dual specificity protein phosphatase 2; dual specificity protein phosphatase PAC-1; dual-specificity phosphatase 2; serine/threonine specific protein phosphatase |
| UniProt Protein Name: | Dual specificity protein phosphatase 2 |
| UniProt Synonym Protein Names: | Dual specificity protein phosphatase PAC-1 |
| Protein Family: | Dual specificity protein phosphatase |
| UniProt Gene Name: | DUSP2 |
| UniProt Entry Name: | DUS2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using DUSP2 antibody (CAB16366) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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