Name: Anti-DUSP19 Antibody (CAB6227)
Brand: Cell Biology Antibodies 10
SKU: CAB6227
Availability: OutOfStock

Antibody Name:	Anti-DUSP19 Antibody
Antibody SKU:	CAB6227
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-95 of human DUSP19 (NP_543152.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse, Rat
Positive Samples:	HeLa, Mouse skeletal muscle, Mouse uterus, Rat skeletal muscle, Rat brain

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-95 of human DUSP19 (NP_543152.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MYSL NQEI KAFS RNNL RKQC TRVT TLTG KKII ETWK DARI HVVE EVEP SSGG GCGY VQDL SSDL QVGV IKPW LLLG SQDA AHDL DTLK KNKV THI
Gene ID:	142679
Uniprot:	Q8WTR2
Cellular Location:
Calculated MW:	18kDa/24kDa
Observed MW:	30kDa

Synonyms:	DUSP19, DUSP17, LMWDSP3, SKRP1, TS-DSP1
Background:

UniProt Protein Function:	DUSP19: Has a dual specificity toward Ser/Thr and Tyr-containing proteins. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Protein phosphatase, dual-specificity; EC 3.1.3.48; EC 3.1.3.16; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 2q32.1 Cellular Component: cytoplasm Molecular Function:protein tyrosine/threonine phosphatase activity; JUN kinase phosphatase activity; MAP-kinase scaffold activity; protein kinase inhibitor activity; protein tyrosine phosphatase activity; mitogen-activated protein kinase kinase kinase binding; protein kinase activator activity Biological Process: negative regulation of JNK activity; negative regulation of JNK cascade; positive regulation of JNK activity; positive regulation of MAPKKK cascade; positive regulation of protein kinase activity; JNK cascade; positive regulation of JNK cascade; negative regulation of protein kinase activity; protein amino acid dephosphorylation; inactivation of MAPK activity
NCBI Summary:	Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP19 contains a variation of the consensus DUSP C-terminal catalytic domain, with the last serine residue replaced by alanine, and lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
UniProt Code:	Q8WTR2
NCBI GenInfo Identifier:	29840769
NCBI Gene ID:	142679
NCBI Accession:	Q8WTR2.1
UniProt Secondary Accession:	Q8WTR2,Q547H4, Q8WYN4, B2RA79,
UniProt Related Accession:	Q8WTR2
Molecular Weight:	217
NCBI Full Name:	Dual specificity protein phosphatase 19
NCBI Synonym Full Names:	dual specificity phosphatase 19
NCBI Official Symbol:	DUSP19
NCBI Official Synonym Symbols:	SKRP1; DUSP17; LMWDSP3; TS-DSP1
NCBI Protein Information:	dual specificity protein phosphatase 19; LMW-DSP3; protein phosphatase SKRP1; dual specificity phosphatase TS-DSP1; SAPK pathway-regulating phosphatase 1; low molecular weight dual specificity phosphatase 3; stress-activated protein kinase pathway-regulating phosphatase 1
UniProt Protein Name:	Dual specificity protein phosphatase 19
UniProt Synonym Protein Names:	Dual specificity phosphatase TS-DSP1; Low molecular weight dual specificity phosphatase 3; LMW-DSP3; Protein phosphatase SKRP1; Stress-activated protein kinase pathway-regulating phosphatase 1; SAPK pathway-regulating phosphatase 1
Protein Family:	Dual specificity protein phosphatase
UniProt Gene Name:	DUSP19
UniProt Entry Name:	DUS19_HUMAN

Western blot analysis of extracts of various cell lines, using DUSP19 antibody (CAB6227) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s.

Antibodies

DUSP19 Antibody (PACO00727)

DUSP19 Antibody (PACO08955)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)