Cell Biology Antibodies 3
Anti-DUSP12 Antibody (CAB13247)
- SKU:
- CAB13247
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Antibody Name: | Anti-DUSP12 Antibody |
Antibody SKU: | CAB13247 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB |
Reactivity: | Human, Mouse |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 130-270 of human DUSP12 (NP_009171.1). |
Application: | WB |
Recommended Dilution: | WB 1:500 - 1:2000 |
Reactivity: | Human, Mouse |
Positive Samples: | Jurkat, A-549 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 130-270 of human DUSP12 (NP_009171.1). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | LMKT DQLP FEKA YEKL QILK PEAK MNEG FEWQ LKLY QAMG YEVD TSSA IYKQ YRLQ KVTE KYPE LQNL PQEL FAVD PTTV SQGL KDEV LYKC RKCR RSLF RSSS ILDH REGS GPIA FAHK RMTP SSML TTGR QAQC TSYF I |
Gene ID: | 11266 |
Uniprot: | Q9UNI6 |
Cellular Location: | Nucleus |
Calculated MW: | 37kDa |
Observed MW: | 36kDa |
Synonyms: | DUSP12, DUSP1, YVH1 |
Background: | The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain. |
UniProt Protein Function: | DUSP12: is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain. [provided by RefSeq, Jul 2008] |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; EC 3.1.3.16; EC 3.1.3.48; Protein phosphatase, dual-specificity Chromosomal Location of Human Ortholog: 1q21-q22 Cellular Component: cytoplasm; nucleus Molecular Function:zinc ion binding; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; kinase binding Biological Process: protein modification process; protein amino acid dephosphorylation; positive regulation of glucokinase activity |
NCBI Summary: | The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9UNI6 |
NCBI GenInfo Identifier: | 9973073 |
NCBI Gene ID: | 11266 |
NCBI Accession: | Q9UNI6.1 |
UniProt Secondary Accession: | Q9UNI6,Q9D0T2, |
UniProt Related Accession: | Q9UNI6 |
Molecular Weight: | 340 |
NCBI Full Name: | Dual specificity protein phosphatase 12 |
NCBI Synonym Full Names: | dual specificity phosphatase 12 |
NCBI Official Symbol: | DUSP12 |
NCBI Official Synonym Symbols: | YVH1; DUSP1 |
NCBI Protein Information: | dual specificity protein phosphatase 12; YVH1 protein-tyrosine phosphatase ortholog; dual specificity tyrosine phosphatase YVH1; serine/threonine specific protein phosphatase |
UniProt Protein Name: | Dual specificity protein phosphatase 12 |
UniProt Synonym Protein Names: | Dual specificity tyrosine phosphatase YVH1 |
Protein Family: | Dual specificity protein phosphatase |
UniProt Gene Name: | DUSP12 |
UniProt Entry Name: | DUS12_HUMAN |
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