Cell Biology Antibodies 15
Anti-DTX3L Antibody (CAB18551)
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- SKU:
- CAB18551
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-DTX3L Antibody |
| Antibody SKU: | CAB18551 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human DTX3L. |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse thymus |
| Immunogen: | Recombinant protein of human DTX3L. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 151636 |
| Uniprot: | Q8TDB6 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | 84kDa |
 | Western blot - DTX3L Rabbit pAb (CAB18551) |
| Synonyms: | BBAP, DTX3L |
| Background: |
| UniProt Protein Function: | DTX3L: Ubiquitin ligase that mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post- translational modifications such as H4 'Lys-20' methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation. Belongs to the Deltex family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Ubiquitin conjugating system; Ubiquitin ligase; EC 6.3.2.-; Ligase Chromosomal Location of Human Ortholog: 3q21.1 Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus Molecular Function:histone binding; protein binding; ubiquitin-protein ligase activity Biological Process: double-strand break repair; histone monoubiquitination; protein polyubiquitination; response to DNA damage stimulus |
| NCBI Summary: | DTX3L functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009] |
| UniProt Code: | Q8TDB6 |
| NCBI GenInfo Identifier: | 37077418 |
| NCBI Gene ID: | 151636 |
| NCBI Accession: | Q8TDB6.1 |
| UniProt Secondary Accession: | Q8TDB6,Q53ZZ3, Q5MJP7, B3KWH6, |
| UniProt Related Accession: | Q8TDB6 |
| Molecular Weight: | 25,792 Da |
| NCBI Full Name: | E3 ubiquitin-protein ligase DTX3L |
| NCBI Synonym Full Names: | deltex E3 ubiquitin ligase 3L |
| NCBI Official Symbol: | DTX3L |
| NCBI Official Synonym Symbols: | BBAP |
| NCBI Protein Information: | E3 ubiquitin-protein ligase DTX3L |
| UniProt Protein Name: | E3 ubiquitin-protein ligase DTX3L |
| UniProt Synonym Protein Names: | B-lymphoma- and BAL-associated protein; Protein deltex-3-like; Rhysin-2; Rhysin2 |
| Protein Family: | E3 ubiquitin-protein ligase |
| UniProt Gene Name: | DTX3L |
| UniProt Entry Name: | DTX3L_HUMAN |
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