Name: Anti-DSTYK Antibody (CAB9870)
Brand: Cell Biology Antibodies 12
SKU: CAB9870
Availability: OutOfStock

Antibody Name:	Anti-DSTYK Antibody
Antibody SKU:	CAB9870
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 635-884 of human DSTYK (NP_955749.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse
Positive Samples:	293T, HeLa, Mouse heart

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 635-884 of human DSTYK (NP_955749.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	RLSL ESCS LQDV LLHR KPKL GQEL GRGQ YGVV YLCD NWGG HFPC ALKS VVPP DEKH WNDL ALEF HYMR SLPK HERL VDLH GSVI DYNY GGGS SIAV LLIM ERLH RDLY TGLK AGLT LETR LQIA LDVV EGIR FLHS QGLV HRDI KLKN VLLD KQNR AKIT DLGF CKPE AMMS GSIV GTPI HMAP ELFT GARP ERLP VFDE ECWQ LMEA CWDG DPLK RPLL GIVQ PMLQ GIMN RLCK SNSE QPNR GLDD ST
Gene ID:	25778
Uniprot:	Q6XUX3
Cellular Location:	Apical cell membrane, Basolateral cell membrane, Cell junction, Cell membrane, Cytoplasm
Calculated MW:	20kDa/66kDa/99kDa/105kDa
Observed MW:	105kDa

Synonyms:	DSTYK, CAKUT1, DustyPK, HDCMD38P, RIP5, RIPK5, SPG23
Background:	This gene encodes a dual serine/threonine and tyrosine protein kinase which is expressed in multiple tissues. It is thought to function as a regulator of cell death. Multiple transcript variants encoding different isoforms have been found for this gene.

UniProt Protein Function:	DSTYK: a serine/threonine protein kinase of the 'Other-Unique' family, most closely related to kinases of the TKL family including IRAK and RIPK. Overexpression induces apoptotic cell death. The caspase inhibitor crmA apparently blocks DNA fragmentation but not apoptosis, suggesting that SgK496 may induce both caspase-dependent apoptosis and caspase-independent cell death. Four alternatively spliced isoforms have been described.
UniProt Protein Details:	Protein type:Protein kinase, Other; EC 2.7.12.1; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Motility/polarity/chemotaxis; Other group; Other-Unique family Chromosomal Location of Human Ortholog: 1q32.1 Cellular Component: apical plasma membrane; basolateral plasma membrane; cell junction; cytoplasm; cytosol Molecular Function:ATP binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein-tyrosine kinase activity Biological Process: peptidyl-tyrosine phosphorylation; positive regulation of fibroblast growth factor receptor signaling pathway; positive regulation of kinase activity Disease: Congenital Anomalies Of Kidney And Urinary Tract, Susceptibility To
NCBI Summary:	This gene encodes a dual serine/threonine and tyrosine protein kinase which is expressed in multiple tissues. It is thought to function as a regulator of cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
UniProt Code:	Q6XUX3
NCBI GenInfo Identifier:	296434486
NCBI Gene ID:	25778
NCBI Accession:	Q6XUX3.2
UniProt Secondary Accession:	Q6XUX3,O75060, Q17R94, Q5RKT0, Q6IN87, Q6P997, Q86Y03 Q9P1S5, B7ZL64,
UniProt Related Accession:	Q6XUX3
Molecular Weight:
NCBI Full Name:	Dual serine/threonine and tyrosine protein kinase
NCBI Synonym Full Names:	dual serine/threonine and tyrosine protein kinase
NCBI Official Symbol:	DSTYK
NCBI Official Synonym Symbols:	RIP5; RIPK5; CAKUT1; DustyPK; HDCMD38P
NCBI Protein Information:	dual serine/threonine and tyrosine protein kinase
UniProt Protein Name:	Dual serine/threonine and tyrosine protein kinase
UniProt Synonym Protein Names:	Dusty protein kinase; Dusty PK; RIP-homologous kinase; Receptor-interacting serine/threonine-protein kinase 5; Sugen kinase 496; SgK496
UniProt Gene Name:	DSTYK
UniProt Entry Name:	DUSTY_HUMAN