Cell Biology Antibodies 8

Anti-DST Antibody (CAB2013)

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SKU:
CAB2013
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-DST Antibody
Antibody SKU:CAB2013
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human DST (NP_001714.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:THP-1, Rat kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human DST (NP_001714.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MHSS SYSY RSSD SVFS NTTS TRTS LDSN ENLL LVHC GPTL INSC ISFG SESF DGHR LEML QQIA NRVQ RDSV ICED KLIL AGNA LQSD SKRL ESGV QFQN EAEI AGYI LECE NLLR QHVI DVQI LIDG KYYQ ADQL VQRV AKLR DEIM ALRN ECSS VYSK GRIL TTEQ TKLM ISGI TQSL NSGF AQTL HPSL TSGL TQSL TPSL TSSS MTSG LSSG MTSR LTPS VTPA YTPG FPSG LVPN FSSG VEPN SLQT LKLM QIRK PLLK SSLL DQ
Gene ID:667
Uniprot:Q03001
Cellular Location:Cell junction, Cell membrane, Cell projection, Cytoplasm, Endoplasmic reticulum membrane, H zone, Lipid-anchor, Membrane, Nucleus, Nucleus envelope, Single-pass membrane protein, Z line, axon, cell cortex, cytoskeleton, cytoskeleton, hemidesmosome, myofibril, sarcomere
Calculated MW:9kDa/25kDa/50kDa/102kDa/306-860kDa
Observed MW:105kDa
Synonyms:DST, BP240, BPA, BPAG1, CATX-15, CATX15, D6S1101, DMH, DT, EBSB2, HSAN6, MACF2, dystonin
Background:This gene encodes a member of the plakin protein family of adhesion junction plaque proteins. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the full-length nature of some variants has not been defined. It has been reported that some isoforms are expressed in neural and muscle tissue, anchoring neural intermediate filaments to the actin cytoskeleton, and some isoforms are expressed in epithelial tissue, anchoring keratin-containing intermediate filaments to hemidesmosomes. Consistent with the expression, mice defective for this gene show skin blistering and neurodegeneration.
UniProt Protein Function:BPAG1 iso3: a protein of the plakin family. Plakins are multi-domain proteins that have been shown to interact with microtubules, actin filaments and intermediate filaments, as well as proteins found in cellular junctions. Ten alternatively spliced human isoforms have been reported. BPAG1 has neuronal and muscle isoforms that consist of actin-binding and microtubule-binding domains at either end separated by a plakin domain and many spectrin repeats. Bpag1 isoforms with different N-termini may have differing roles. The plakin domain contains an apparent nuclear localization signal.
UniProt Protein Details:

Protein type:Microtubule-binding; Cytoskeletal; Motility/polarity/chemotaxis; Actin-binding

Chromosomal Location of Human Ortholog: 6p12.1

Cellular Component: endoplasmic reticulum membrane; intermediate filament cytoskeleton; focal adhesion; cytoplasmic membrane-bound vesicle; leading edge; integral to membrane; intermediate filament; nuclear envelope; cell cortex; Z disc; cytosol; actin cytoskeleton; microtubule cytoskeleton; hemidesmosome; axon; cytoplasm; basal plasma membrane; basement membrane; nucleus

Molecular Function:protein C-terminus binding; integrin binding; microtubule plus-end binding; protein binding; protein homodimerization activity; calcium ion binding; actin binding

Biological Process: integrin-mediated signaling pathway; hemidesmosome assembly; extracellular matrix organization and biogenesis; cell motility involved in cell locomotion; response to wounding; intermediate filament cytoskeleton organization and biogenesis; cytoskeleton organization and biogenesis; microtubule cytoskeleton organization and biogenesis; cell cycle arrest; cell adhesion; maintenance of cell polarity

NCBI Summary:This gene encodes a member of the plakin protein family of adhesion junction plaque proteins. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the full-length nature of some variants has not been defined. It has been reported that some isoforms are expressed in neural and muscle tissue, anchoring neural intermediate filaments to the actin cytoskeleton, and some isoforms are expressed in epithelial tissue, anchoring keratin-containing intermediate filaments to hemidesmosomes. Consistent with the expression, mice defective for this gene show skin blistering and neurodegeneration. [provided by RefSeq, Mar 2010]
UniProt Code:Q03001
NCBI GenInfo Identifier:294862529
NCBI Gene ID:667
NCBI Accession:Q03001.4
UniProt Secondary Accession:Q03001,O94833, Q12825, Q13266, Q13267, Q13775, Q5TBT0 Q5TBT2, Q5TF23, Q5TF24, Q8N1T8, B7Z3H1,
UniProt Related Accession:Q03001
Molecular Weight:7570
NCBI Full Name:Dystonin
NCBI Synonym Full Names:dystonin
NCBI Official Symbol:DST  
NCBI Official Synonym Symbols:DT; BPA; DMH; BP240; BPAG1; EBSB2; HSAN6; MACF2; CATX15; CATX-15; D6S1101  
NCBI Protein Information:dystonin; trabeculin-beta; dystonia musculorum protein; bullous pemphigoid antigen 1; hemidesmosomal plaque protein
UniProt Protein Name:Dystonin
UniProt Synonym Protein Names:230 kDa bullous pemphigoid antigen; 230/240 kDa bullous pemphigoid antigen; Bullous pemphigoid antigen 1; BPA; Bullous pemphigoid antigen; Dystonia musculorum protein; Hemidesmosomal plaque protein
Protein Family:Dystonin
UniProt Gene Name:DST  
UniProt Entry Name:DYST_HUMAN
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