Cell Biology Antibodies 2

Anti-DSG4 Antibody (CAB10502)

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SKU:
CAB10502
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-DSG4 Antibody
Antibody SKU:CAB10502
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 480-630 of human DSG4 (NP_817123.1).
Application:WB
Recommended Dilution:WB 1:1000 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse pancreas, Rat pancreas, A-375, DU145, BxPC-3, Mouse pancreas, Mouse small intestine
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 480-630 of human DSG4 (NP_817123.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:TGTI CIEV PDIN DYCP NIFP ERRT ICID SPSV LISV NEHS YGSP FTFC VVDE PPGI ADMW DVRS TNAT SAIL TAKQ VLSP GFYE IPIL VKDS YNRA CELA QMVQ LYAC DCDD NHMC LDSG AAGI YTED ITGD TYGP VTED QAGV SNVG LGP
Gene ID:147409
Uniprot:Q86SJ6
Cellular Location:Cell junction, Cell membrane, Single-pass type I membrane protein, desmosome
Calculated MW:113kDa/115kDa
Observed MW:114kDa
Synonyms:DSG4, CDGF13, CDHF13, HYPT6, LAH
Background:This gene encodes a member of the desmoglein subgroup of desmosomal cadherins. The encoded protein is a transmembrane component in desmosomes and may play a role in cell-cell adhesion in epithelial cells. Mutations in the gene are associated with localized autosomal recessive hypotrichosis and potentially in other skin disorders. Alternate splicing results in multiple transcript variants.
UniProt Protein Function:Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes.
NCBI Summary:This gene encodes a member of the desmoglein subgroup of desmosomal cadherins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a transmembrane component of desmosomes and may play a role in cell-cell adhesion in epithelial cells. Mutations in the gene are associated with localized autosomal recessive hypotrichosis and monilethrix, characterized by impaired hair growth. [provided by RefSeq, May 2016]
UniProt Code:Q86SJ6
NCBI GenInfo Identifier:60389774
NCBI Gene ID:147409
NCBI Accession:Q86SJ6.1
UniProt Secondary Accession:Q86SJ6,Q6Y9L9, Q8IXV4, A2RUI1,
UniProt Related Accession:Q86SJ6
Molecular Weight:114kDa
NCBI Full Name:Desmoglein-4
NCBI Synonym Full Names:desmoglein 4
NCBI Official Symbol:DSG4  
NCBI Official Synonym Symbols:LAH; HYPT6; CDGF13; CDHF13  
NCBI Protein Information:desmoglein-4
UniProt Protein Name:Desmoglein-4
UniProt Synonym Protein Names:Cadherin family member 13
Protein Family:Desmoglein
UniProt Gene Name:DSG4  
Anti-DSG4 Antibody (CAB10502)Western blot analysis of extracts of various cell lines, using DSG4 antibody (CAB10502) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
Anti-DSG4 Antibody (CAB10502)Western blot analysis of extracts of various cell lines, using DSG4 antibody (CAB10502) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
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