Cell Biology Antibodies 1
Anti-DSC2 Antibody (CAB10211)
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- SKU:
- CAB10211
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-DSC2 Antibody |
| Antibody SKU: | CAB10211 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 520-690 of human DSC2 (NP_077740.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | A-431, Raji, LO2, BT-474, HT-29 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 520-690 of human DSC2 (NP_077740.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | IDEN TGSI KVFR SLDR EAET IKNG IYNI TVLA SDQG GRTC TGTL GIIL QDVN DNSP FIPK KTVI ICKP TMSS AEIV AVDP DEPI HGPP FDFS LESS TSEV QRMW RLKA INDT AARL SYQN DPPF GSYV VPIT VRDR LGMS SVTS LDVT LCDC ITEN DCTH RVDP RIGG GGV |
| Gene ID: | 1824 |
| Uniprot: | Q02487 |
| Cellular Location: | Cell junction, Cell membrane, Single-pass type I membrane protein, desmosome |
| Calculated MW: | 93kDa/99kDa |
| Observed MW: | 100kDa |
| Synonyms: | DSC2, ARVD11, CDHF2, DG2, DGII/III, DSC3 |
| Background: | This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. |
| NCBI Summary: | This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015] |
| UniProt Code: | Q02487 |
| NCBI GenInfo Identifier: | 461968 |
| NCBI Gene ID: | 1824 |
| NCBI Accession: | Q02487.1 |
| UniProt Related Accession: | Q02487 |
| Molecular Weight: | 100kDa |
| NCBI Full Name: | Desmocollin-2 |
| NCBI Synonym Full Names: | desmocollin 2 |
| NCBI Official Symbol: | DSC2 |
| NCBI Official Synonym Symbols: | DG2; DSC3; CDHF2; ARVD11; DGII/III |
| NCBI Protein Information: | desmocollin-2 |
| UniProt Protein Name: | Desmocollin-2 |
| UniProt Synonym Protein Names: | Cadherin family member 2; Desmocollin-3; Desmosomal glycoprotein II; Desmosomal glycoprotein III |
| Protein Family: | Desmocollin |
| UniProt Gene Name: | DSC2 |
 | Western blot analysis of extracts of various cell lines, using DSC2 antibody (CAB10211) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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