Cell Biology Antibodies 1

Anti-DSC1 Antibody (CAB10061)

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SKU:
CAB10061
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-DSC1 Antibody
Antibody SKU:CAB10061
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 480-690 of human DSC1 (NP_077739.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Raji, Mouse liver, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 480-690 of human DSC1 (NP_077739.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SQDG FPAG QELL GYKA LDPE ISSG EGLR YQKL GDED NWFE INQH TGDL RTLK VLDR ESKF VKNN QYNI SVVA VDAV GRSC TGTL VVHL DDYN DHAP QIDK EVTI CQNN EDFA VLKP VDPD GPEN GPPF QFFL DNSA SKNW NIEE KDGK TAIL RQRQ NLDY NYYS VPIQ IKDR HGLV ATHM LTVR VCDC STPS ECRM KDKS TRDV RPNV ILG
Gene ID:1823
Uniprot:Q08554
Cellular Location:Cell junction, Cell membrane, Single-pass type I membrane protein, desmosome
Calculated MW:93kDa/99kDa
Observed MW:105kDa
Synonyms:DSC1, CDHF1, DG2/DG3
Background:The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. A subtype of IgA pemphigus, a life-threatening autoimmune disease, is characterized by the presence of autoantibodies that target the encoded protein. The desmosomal family members are arranged in two clusters on chromosome 18. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protein.
UniProt Protein Function:Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues.
NCBI Summary:The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. A subtype of IgA pemphigus, a life-threatening autoimmune disease, is characterized by the presence of autoantibodies that target the encoded protein. The desmosomal family members are arranged in two clusters on chromosome 18. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protein. [provided by RefSeq, Nov 2015]
UniProt Code:Q08554
NCBI GenInfo Identifier:223590198
NCBI Gene ID:1823
NCBI Accession:Q08554.2
UniProt Secondary Accession:Q08554,Q9HB01,
UniProt Related Accession:Q08554
Molecular Weight:93,835 Da
NCBI Full Name:Desmocollin-1
NCBI Synonym Full Names:desmocollin 1
NCBI Official Symbol:DSC1  
NCBI Official Synonym Symbols:CDHF1; DG2/DG3  
NCBI Protein Information:desmocollin-1
UniProt Protein Name:Desmocollin-1
UniProt Synonym Protein Names:Cadherin family member 1; Desmosomal glycoprotein 2/3; DG2/DG3
Protein Family:Desmocollin
UniProt Gene Name:DSC1  
UniProt Entry Name:DSC1_HUMAN
Anti-DSC1 Antibody (CAB10061)Western blot analysis of extracts of various cell lines, using DSC1 antibody (CAB10061) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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