Cell Biology Antibodies 8
Anti-DRD5 Antibody (CAB3170)
- SKU:
- CAB3170
- Product Type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-DRD5 Antibody |
| Antibody SKU: | CAB3170 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 361-477 of human DRD5 (NP_000789.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Rat |
| Positive Samples: | Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 361-477 of human DRD5 (NP_000789.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | FNAD FQKV FAQL LGCS HFCS RTPV ETVN ISNE LISY NQDI VFHK EIAA AYIH MMPN AVTP GNRE VDND EEEG PFDR MFQI YQTS PDGD PVAE SVWE LDCE GEIS LDKI TPFT PNGF H |
| Gene ID: | 1816 |
| Uniprot: | P21918 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 52kDa |
| Observed MW: | 53kDa |
| Synonyms: | DRD5, DBDR, DRD1B, DRD1L2 |
| Background: | This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2. |
| UniProt Protein Function: | DRD5: Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. Defects in DRD5 are a cause of benign essential blepharospasm (BEB). BEB is a primary focal dystonia affecting the orbicularis oculi muscles. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. BEB usually begins in middle age. Initial symptoms include eye irritation and frequent blinking, progressing to involuntary spasms of eyelid closure. Patients have normal eyes. The visual disturbance is due solely to the forced closure of the eyelids. In severe cases, this can lead to functional blindness. Belongs to the G-protein coupled receptor 1 family. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR Chromosomal Location of Human Ortholog: 4p16.1 Cellular Component: brush border membrane; integral to plasma membrane; nonmotile primary cilium; plasma membrane Molecular Function:dopamine binding; dopamine D1 receptor-like receptor activity; dopamine receptor activity Biological Process: adenylate cyclase activation; associative learning; cellular calcium ion homeostasis; dopamine receptor, adenylate cyclase activating pathway; dopamine receptor, phospholipase C activating pathway; G-protein signaling, adenylate cyclase activating pathway; learning; negative regulation of blood pressure; negative regulation of NAD(P)H oxidase activity; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure; positive regulation of adenylate cyclase activity; regulation of female receptivity; regulation of systemic arterial blood pressure by vasopressin; response to amphetamine; response to cocaine; sensitization; synaptic transmission; synaptic transmission, dopaminergic; transmission of nerve impulse; wound healing Disease: Attention Deficit-hyperactivity Disorder; Blepharospasm, Benign Essential |
| NCBI Summary: | This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P21918 |
| NCBI GenInfo Identifier: | 118214 |
| NCBI Gene ID: | 1816 |
| NCBI Accession: | P21918.2 |
| UniProt Secondary Accession: | P21918,Q8NEQ8, B2R9S3, |
| UniProt Related Accession: | P21918 |
| Molecular Weight: | 52,951 Da |
| NCBI Full Name: | D(1B) dopamine receptor |
| NCBI Synonym Full Names: | dopamine receptor D5 |
| NCBI Official Symbol: | DRD5 |
| NCBI Official Synonym Symbols: | DBDR; DRD1B; DRD1L2 |
| NCBI Protein Information: | D(1B) dopamine receptor |
| UniProt Protein Name: | D(1B) dopamine receptor |
| UniProt Synonym Protein Names: | D(5) dopamine receptor; D1beta dopamine receptor; Dopamine D5 receptor |
| Protein Family: | D(1B) dopamine receptor |
| UniProt Gene Name: | DRD5 |
| UniProt Entry Name: | DRD5_HUMAN |
 | Western blot analysis of extracts of rat brain, using DRD5 antibody (CAB3170) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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