Cell Biology Antibodies 13

Anti-DRAP1 Antibody (CAB17616)

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SKU:
CAB17616
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-DRAP1 Antibody
Antibody SKU:CAB17616
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 50-150 of human DRAP1 (NP_006433.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, Jurkat, 293T, Rat testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 50-150 of human DRAP1 (NP_006433.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LKKA CQVT QSRN AKTM TTSH LKQC IELE QQFD FLKD LVAS VPDM QGDG EDNH MDGD KGAR RGRK PGSG GRKN GGMG TKSK DKKL SGTD SEQE DESE DTDT D
Gene ID:10589
Uniprot:Q14919
Cellular Location:
Calculated MW:
Observed MW:32-38kDa
Anti-DRAP1 Antibody (CAB17616)Western blot - DRAP1 Polyclonal Antibody (CAB17616)
Synonyms:NC2-alpha, DRAP1
Background:Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex. [provided by RefSeq, Jul 2008]
UniProt Protein Function:The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own.
NCBI Summary:Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex. [provided by RefSeq, Jul 2008]
UniProt Code:Q14919
NCBI GenInfo Identifier:56404465
NCBI Gene ID:10589
NCBI Accession:Q14919.3
UniProt Secondary Accession:Q14919,Q13448,
UniProt Related Accession:Q14919
Molecular Weight:23,148 Da
NCBI Full Name:Dr1-associated corepressor
NCBI Synonym Full Names:DR1 associated protein 1
NCBI Official Symbol:DRAP1  
NCBI Official Synonym Symbols:NC2-alpha  
NCBI Protein Information:dr1-associated corepressor
UniProt Protein Name:Dr1-associated corepressor
UniProt Synonym Protein Names:Dr1-associated protein 1; Negative cofactor 2-alpha; NC2-alpha
Protein Family:Dr1-associated corepressor
UniProt Gene Name:DRAP1  
UniProt Entry Name:NC2A_HUMAN
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