Cell Biology Antibodies 13
Anti-DRAP1 Antibody (CAB17616)
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- SKU:
- CAB17616
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-DRAP1 Antibody |
| Antibody SKU: | CAB17616 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-150 of human DRAP1 (NP_006433.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, Jurkat, 293T, Rat testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-150 of human DRAP1 (NP_006433.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LKKA CQVT QSRN AKTM TTSH LKQC IELE QQFD FLKD LVAS VPDM QGDG EDNH MDGD KGAR RGRK PGSG GRKN GGMG TKSK DKKL SGTD SEQE DESE DTDT D |
| Gene ID: | 10589 |
| Uniprot: | Q14919 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | 32-38kDa |
 | Western blot - DRAP1 Polyclonal Antibody (CAB17616) |
| Synonyms: | NC2-alpha, DRAP1 |
| Background: | Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. |
| NCBI Summary: | Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q14919 |
| NCBI GenInfo Identifier: | 56404465 |
| NCBI Gene ID: | 10589 |
| NCBI Accession: | Q14919.3 |
| UniProt Secondary Accession: | Q14919,Q13448, |
| UniProt Related Accession: | Q14919 |
| Molecular Weight: | 23,148 Da |
| NCBI Full Name: | Dr1-associated corepressor |
| NCBI Synonym Full Names: | DR1 associated protein 1 |
| NCBI Official Symbol: | DRAP1 |
| NCBI Official Synonym Symbols: | NC2-alpha |
| NCBI Protein Information: | dr1-associated corepressor |
| UniProt Protein Name: | Dr1-associated corepressor |
| UniProt Synonym Protein Names: | Dr1-associated protein 1; Negative cofactor 2-alpha; NC2-alpha |
| Protein Family: | Dr1-associated corepressor |
| UniProt Gene Name: | DRAP1 |
| UniProt Entry Name: | NC2A_HUMAN |
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