Cell Death Antibodies 1
Anti-DRAM1 Antibody (CAB15468)
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- SKU:
- CAB15468
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-DRAM1 Antibody |
| Antibody SKU: | CAB15468 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human DRAM1 (NP_060840.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse lung, Mouse liver, Mouse kidney |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human DRAM1 (NP_060840.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GLVG CFGM GIVA NFQE LAVP VVHD GGAL LAFV CGVV YTLL QSII SYKS CPQW NSLS TCHI RMVI SAVS CAAV IPMI VCAS LISI TKLE WNPR EKDY VYHV V |
| Gene ID: | 55332 |
| Uniprot: | Q8N682 |
| Cellular Location: | Lysosome membrane, Multi-pass membrane protein |
| Calculated MW: | 13kDa/26kDa |
| Observed MW: | 26kDa |
| Synonyms: | DRAM1, DRAM |
| Background: | This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4. |
| UniProt Protein Function: | DRAM1: Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73- mediated autophagy. Belongs to the DRAM/TMEM150 family. |
| UniProt Protein Details: | Protein type:Apoptosis; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 12q23.2 Cellular Component: lysosome; lysosomal membrane; cytoplasm; integral to membrane Biological Process: apoptosis; autophagy; regulation of autophagy |
| NCBI Summary: | This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8N682 |
| NCBI GenInfo Identifier: | 22450862 |
| NCBI Gene ID: | 55332 |
| NCBI Accession: | AAH18435 |
| UniProt Secondary Accession: | Q8N682,Q7L3E3, Q9NUN1, B7Z4T0, |
| UniProt Related Accession: | Q8N682 |
| Molecular Weight: | 13,972 Da |
| NCBI Full Name: | Damage-regulated autophagy modulator |
| NCBI Synonym Full Names: | DNA-damage regulated autophagy modulator 1 |
| NCBI Official Symbol: | DRAM1 |
| NCBI Official Synonym Symbols: | DRAM |
| NCBI Protein Information: | DNA damage-regulated autophagy modulator protein 1 |
| UniProt Protein Name: | DNA damage-regulated autophagy modulator protein 1 |
| UniProt Synonym Protein Names: | Damage-regulated autophagy modulator |
| UniProt Gene Name: | DRAM1 |
| UniProt Entry Name: | DRAM1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using DRAM1 antibody (CAB15468) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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