Epigenetics & Nuclear Signaling Antibodies 4
Anti-DR1 Antibody (CAB6903)
- SKU:
- CAB6903
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Antibody Name: | Anti-DR1 Antibody |
Antibody SKU: | CAB6903 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB IHC IF |
Reactivity: | Human, Mouse, Rat |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-176 of human DR1 (NP_001929.1). |
Application: | WB IHC IF |
Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
Reactivity: | Human, Mouse, Rat |
Positive Samples: | HL-60, THP-1, Jurkat, HepG2 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-176 of human DR1 (NP_001929.1). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | MASS SGND DDLT IPRA AINK MIKE TLPN VRVA NDAR ELVV NCCT EFIH LISS EANE ICNK SEKK TISP EHVI QALE SLGF GSYI SEVK EVLQ ECKT VALK RRKA SSRL ENLG IPEE ELLR QQQE LFAK ARQQ QAEL AQQE WLQM QQAA QQAQ LAAA SASA SNQA GSSQ DEED DDDI |
Gene ID: | 1810 |
Uniprot: | Q01658 |
Cellular Location: | Nucleus |
Calculated MW: | 19kDa |
Observed MW: | 19kDa |
Synonyms: | DR1, NC2, NC2-BETA, NC2B, NCB2 |
Background: | This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription. |
UniProt Protein Function: | DR1: The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Heterodimer with DRAP1. DR1 exists in solution as a homotetramer that dissociates during interaction with TBP and then, after complexing with TBP, reassociates at a slow rate, to reconstitute the tetramer. Interacts with NFIL3. Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. Belongs to the NC2 beta/DR1 family. |
UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 1p22.1 Cellular Component: nucleus Molecular Function:protein binding; TATA-binding protein binding; transcription corepressor activity; transcription factor binding Biological Process: negative regulation of transcription from RNA polymerase II promoter |
NCBI Summary: | This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q01658 |
NCBI GenInfo Identifier: | 401162 |
NCBI Gene ID: | 1810 |
NCBI Accession: | Q01658.1 |
UniProt Related Accession: | Q01658 |
Molecular Weight: | 19,444 Da |
NCBI Full Name: | Protein Dr1 |
NCBI Synonym Full Names: | down-regulator of transcription 1 |
NCBI Official Symbol: | DR1 |
NCBI Official Synonym Symbols: | NC2; NC2B; NC2-BETA |
NCBI Protein Information: | protein Dr1 |
UniProt Protein Name: | Protein Dr1 |
UniProt Synonym Protein Names: | Down-regulator of transcription 1; Negative cofactor 2-beta; NC2-beta; TATA-binding protein-associated phosphoprotein |
Protein Family: | Dr1-associated corepressor |
UniProt Gene Name: | DR1 |
UniProt Entry Name: | NC2B_HUMAN |
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