Cell Biology Antibodies 6
Anti-DPP9 Antibody (CAB15548)
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- SKU:
- CAB15548
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-DPP9 Antibody |
| Antibody SKU: | CAB15548 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human DPP9 (NP_631898.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | LO2, HT-29, OVCAR3 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human DPP9 (NP_631898.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MRKV KKLR LDKE NTGS WRSF SLNS EGAE RMAT TGTP TADR GDAA ATDD PAAR FQVQ KHSW DGLR SIIH GSRK YSGL IVNK APHD FQFV QKTD ESGP HSHR |
| Gene ID: | 91039 |
| Uniprot: | Q86TI2 |
| Cellular Location: | Cytoplasm, Nucleus, cytosol |
| Calculated MW: | 95kDa/98kDa/101kDa |
| Observed MW: | 100kDa |
| Synonyms: | DPP9, DP9, DPLP9, DPRP-2, DPRP2 |
| Background: | This gene encodes a protein that is a member of the S9B family in clan SC of the serine proteases. The protein has been shown to have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Although the activity of this protein is similar to that of dipeptidyl peptidase 4 (DPP4), it does not appear to be membrane bound. In general, dipeptidyl peptidases appear to be involved in the regulation of the activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. Several transcript variants of this gene have been described but not fully characterized. |
| UniProt Protein Function: | DPP9: Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. Belongs to the peptidase S9B family. DPPIV subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.4.14.5; Protease Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: membrane; cytoplasm; nucleus; cytosol Molecular Function:identical protein binding; serine-type peptidase activity; aminopeptidase activity Biological Process: proteolysis |
| NCBI Summary: | This gene encodes a protein that is a member of the S9B family in clan SC of the serine proteases. The protein has been shown to have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Although the activity of this protein is similar to that of dipeptidyl peptidase 4 (DPP4), it does not appear to be membrane bound. In general, dipeptidyl peptidases appear to be involved in the regulation of the activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. Several transcript variants of this gene have been described but not fully characterized. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q86TI2 |
| NCBI GenInfo Identifier: | 194394146 |
| NCBI Gene ID: | 91039 |
| NCBI Accession: | NP_631898.3 |
| UniProt Secondary Accession: | Q86TI2,O75273, O75868, Q1ZZB8, Q6AI37, Q6UAL0, Q6ZMT2 Q6ZNJ5, Q8N2J7, Q8N3F5, Q8WXD8, Q96NT8, |
| UniProt Related Accession: | Q86TI2 |
| Molecular Weight: | 95,013 Da |
| NCBI Full Name: | dipeptidyl peptidase 9 |
| NCBI Synonym Full Names: | dipeptidyl-peptidase 9 |
| NCBI Official Symbol: | DPP9 |
| NCBI Official Synonym Symbols: | DP9; DPLP9; DPRP2; DPRP-2 |
| NCBI Protein Information: | dipeptidyl peptidase 9 |
| UniProt Protein Name: | Dipeptidyl peptidase 9 |
| UniProt Synonym Protein Names: | Dipeptidyl peptidase IV-related protein 2; DPRP-2; Dipeptidyl peptidase IX; DPP IX; Dipeptidyl peptidase-like protein 9; DPLP9 |
| Protein Family: | Dipeptidyl peptidase |
| UniProt Gene Name: | DPP9 |
| UniProt Entry Name: | DPP9_HUMAN |
 | Western blot analysis of extracts of various cell lines, using DPP9 antibody (CAB15548) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10S. |
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