Cell Death Antibodies 2

Anti-DPP8 Antibody (CAB7113)

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SKU:
CAB7113
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death

Description

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Antibody Name:Anti-DPP8 Antibody
Antibody SKU:CAB7113
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 10-230 of human DPP8 (NP_932065.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:HL-60, MCF7, NCI-H460, HeLa, Mouse brain, Mouse lung, Mouse skeletal muscle, Rat lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 10-230 of human DPP8 (NP_932065.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:IKSG KCNM AAAM ETEQ LGVE IFET ADCE ENIE SQDR PKLE PFYV ERYS WSQL KKLL ADTR KYHG YMMA KAPH DFMF VKRN DPDG PHSD RIYY LAMS GENR ENTL FYSE IPKT INRA AVLM LSWK PLLD LFQA TLDY GMYS REEE LLRE RKRI GTVG IASY DYHQ GSGT FLFQ AGSG IYHV KDGG PQGF TQQP LRPN LVET SCPN IRMD PKLC PADP DWIA F
Gene ID:54878
Uniprot:Q6V1X1
Cellular Location:Cytoplasm
Calculated MW:83kDa/89kDa/97kDa/101kDa/103kDa
Observed MW:103kDa
Synonyms:DPP8, DP8, DPRP-1, DPRP1, MST097, MSTP097, MSTP135, MSTP141
Background:This gene encodes a member of the peptidase S9B family, a small family of dipeptidyl peptidases that are able to cleave peptide substrates at a prolyl bond. The encoded protein shares similarity with dipeptidyl peptidase IV in that it is ubiquitously expressed, and hydrolyzes the same substrates. These similarities suggest that, like dipeptidyl peptidase IV, this protein may play a role in T-cell activation and immune function. Alternatively spliced transcript variants encoding different isoforms have been described.
UniProt Protein Function:DPP8: Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. May play a role in T-cell activation and immune function. Belongs to the peptidase S9B family. DPPIV subfamily. 6 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Protease; EC 3.4.14.5

Chromosomal Location of Human Ortholog: 15q22

Cellular Component: nucleoplasm; membrane; cytoplasm

Molecular Function:dipeptidyl-peptidase activity; serine-type peptidase activity

Biological Process: immune response; proteolysis

NCBI Summary:This gene encodes a member of the peptidase S9B family, a small family of dipeptidyl peptidases that are able to cleave peptide substrates at a prolyl bond. The encoded protein shares similarity with dipeptidyl peptidase IV in that it is ubiquitously expressed, and hydrolyzes the same substrates. These similarities suggest that, like dipeptidyl peptidase IV, this protein may play a role in T-cell activation and immune function. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
UniProt Code:Q6V1X1
NCBI GenInfo Identifier:67460301
NCBI Gene ID:54878
NCBI Accession:Q6V1X1.1
UniProt Secondary Accession:Q6V1X1,Q7Z4C8, Q7Z4D3, Q7Z4E1, Q8IWG7, Q8NEM5, Q96JX1 Q9HBM2, Q9HBM3, Q9HBM4, Q9HBM5, Q9NXF4,
UniProt Related Accession:Q6V1X1
Molecular Weight:898
NCBI Full Name:Dipeptidyl peptidase 8
NCBI Synonym Full Names:dipeptidyl-peptidase 8
NCBI Official Symbol:DPP8  
NCBI Official Synonym Symbols:DP8; DPRP1; MSTP141  
NCBI Protein Information:dipeptidyl peptidase 8; DPRP-1; DPP VIII; dipeptidylpeptidase 8; prolyl dipeptidase DPP8; dipeptidyl peptidase VIII; dipeptidyl peptidase IV-related protein 1; dipeptidyl peptidase IV-related protein-1
UniProt Protein Name:Dipeptidyl peptidase 8
UniProt Synonym Protein Names:Dipeptidyl peptidase IV-related protein 1; DPRP-1; Dipeptidyl peptidase VIII; DPP VIII; Prolyl dipeptidase DPP8
Protein Family:Dipeptidyl peptidase
UniProt Gene Name:DPP8  
UniProt Entry Name:DPP8_HUMAN
Anti-DPP8 Antibody (CAB7113)Western blot analysis of extracts of various cell lines, using DPP8 antibody (CAB7113) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
Anti-DPP8 Antibody (CAB7113)Immunofluorescence analysis of A549 cells using DPP8 antibody (CAB7113). Blue: DAPI for nuclear staining.
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