Cell Biology Antibodies 5
Anti-DPP4 Antibody (CAB1455)
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- SKU:
- CAB1455
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-DPP4 Antibody |
| Antibody SKU: | CAB1455 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-280 of human DPP4 (NP_001926.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Raji, HepG2, HeLa, 293T, SKOV3, Mouse thymus, Mouse liver, Rat kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-280 of human DPP4 (NP_001926.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | NKGT DDAT ADSR KTYT LTDY LKNT YRLK LYSL RWIS DHEY LYKQ ENNI LVFN AEYG NSSV FLEN STFD EFGH SIND YSIS PDGQ FILL EYNY VKQW RHSY TASY DIYD LNKR QLIT EERI PNNT QWVT WSPV GHKL AYVW NNDI YVKI EPNL PSYR ITWT GKED IIYN GITD WVYE EEVF SAYS ALWW SPNG TFLA YAQF NDTE VPLI EYSF YSDE SLQY PKTV RVPY PKAG AVNP TVKF FVVN TDSL SSVT |
| Gene ID: | 1803 |
| Uniprot: | P27487 |
| Cellular Location: | Apical cell membrane, Cell junction, Cell membrane, Cell projection, Membrane raft, Secreted, Single-pass type II membrane protein, invadopodium membrane, lamellipodium membrane |
| Calculated MW: | 88kDa |
| Observed MW: | 110kDa |
| Synonyms: | DPP4, ADABP, ADCP2, CD26, DPPIV, TP103 |
| Background: | The protein encoded by this gene is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. |
| UniProt Protein Function: | DPP4: Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF- kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. Belongs to the peptidase S9B family. DPPIV subfamily. |
| UniProt Protein Details: | Protein type:Cell surface; Membrane protein, integral; Cell adhesion; Protease; EC 3.4.14.5 Chromosomal Location of Human Ortholog: 2q24.3 Cellular Component: intercellular canaliculus; cell surface; focal adhesion; membrane; endocytic vesicle; lysosomal membrane; lamellipodium; apical plasma membrane; integral to membrane; plasma membrane; lipid raft Molecular Function:identical protein binding; protein binding; protein homodimerization activity; protease binding; dipeptidyl-peptidase activity; serine-type peptidase activity; serine-type endopeptidase activity; receptor binding Biological Process: regulation of cell-cell adhesion mediated by integrin; T cell activation; positive regulation of cell proliferation; T cell costimulation; response to hypoxia; endothelial cell migration; proteolysis |
| NCBI Summary: | The protein encoded by this gene is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P27487 |
| NCBI GenInfo Identifier: | 1352311 |
| NCBI Gene ID: | 1803 |
| NCBI Accession: | P27487.2 |
| UniProt Secondary Accession: | P27487,Q53TN1, |
| UniProt Related Accession: | P27487 |
| Molecular Weight: | 88,279 Da |
| NCBI Full Name: | Dipeptidyl peptidase 4 |
| NCBI Synonym Full Names: | dipeptidyl-peptidase 4 |
| NCBI Official Symbol: | DPP4 |
| NCBI Official Synonym Symbols: | CD26; ADABP; ADCP2; DPPIV; TP103 |
| NCBI Protein Information: | dipeptidyl peptidase 4; ADCP-2; DPP IV; dipeptidylpeptidase 4; dipeptidyl peptidase IV; T-cell activation antigen CD26; adenosine deaminase complexing protein 2; dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2) |
| UniProt Protein Name: | Dipeptidyl peptidase 4 |
| UniProt Synonym Protein Names: | ADABP; Adenosine deaminase complexing protein 2; ADCP-2; Dipeptidyl peptidase IV; DPP IV; T-cell activation antigen CD26; TP103; CD_antigen: CD26Cleaved into the following 2 chains:Dipeptidyl peptidase 4 membrane formAlternative name(s):Dipeptidyl peptidase IV membrane form |
| Protein Family: | Dipeptidyl peptidase |
| UniProt Gene Name: | DPP4 |
| UniProt Entry Name: | DPP4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using DPP4 antibody (CAB1455) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
 | Immunofluorescence analysis of L929 cells using DPP4 Rabbit pAb (CAB1455) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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