Cell Biology Antibodies 3
Anti-DPP3 Antibody (CAB13390)
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- SKU:
- CAB13390
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-DPP3 Antibody |
| Antibody SKU: | CAB13390 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human DPP3 (NP_569710.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | BT-474, HT-29, SKOV3, MCF7, Mouse liver, Rat liver, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human DPP3 (NP_569710.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MADT QYIL PNDI GVSS LDCR EAFR LLSP TERL YAYH LSRA AWYG GLAV LLQT SPEA PYIY ALLS RLFR AQDP DQLR QHAL AEGL TEEE YQAF LVYA AGVY SNMG NYKS FGDT KFVP NLPK EKLE RVIL GSEA AQQH PEEV RGLW QTCG ELMF SLEP RLRH LGLG KEGI TTYF SGNC TMED AKLA QDFL DSQN LSAY NTRL FKEV DGEG KPYY EVRL ASVL GSEP SLDS EVTS KLKS YEFR GSPF QVTR GDYA PILQ KVVE QLEK AKAY AANS HQGQ MLAQ |
| Gene ID: | 10072 |
| Uniprot: | Q9NY33 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 35kDa/69kDa/79kDa/82kDa |
| Observed MW: | 83kDa |
| Synonyms: | DPP3, DPPIII |
| Background: | This gene encodes a protein that is a member of the M49 family of metallopeptidases. This cytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Increased activity of this protein is associated with endometrial and ovarian cancers. Alternatively spliced transcript variants have been found for this gene. |
| UniProt Protein Function: | DPP3: Cleaves Arg-Arg-beta-naphthylamide. Belongs to the peptidase M49 family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.4.14.4; Protease Chromosomal Location of Human Ortholog: 11q13.2 Cellular Component: nucleoplasm; cytoplasm; plasma membrane Molecular Function:protein binding; zinc ion binding; metallopeptidase activity; dipeptidyl-peptidase activity Biological Process: proteolysis |
| NCBI Summary: | This gene encodes a protein that is a member of the M49 family of metallopeptidases. This cytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Increased activity of this protein is associated with endometrial and ovarian cancers. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2012] |
| UniProt Code: | Q9NY33 |
| NCBI GenInfo Identifier: | 20532389 |
| NCBI Gene ID: | 10072 |
| NCBI Accession: | Q9NY33.2 |
| UniProt Secondary Accession: | Q9NY33,O95748, Q969H2, Q9BV67, Q9HAL6, B2RDB5, B4DLX4 F5H8L6, |
| UniProt Related Accession: | Q9NY33 |
| Molecular Weight: | 737 |
| NCBI Full Name: | Dipeptidyl peptidase 3 |
| NCBI Synonym Full Names: | dipeptidyl-peptidase 3 |
| NCBI Official Symbol: | DPP3 |
| NCBI Official Synonym Symbols: | DPPIII |
| NCBI Protein Information: | dipeptidyl peptidase 3; DPP III; enkephalinase B; dipeptidyl peptidase III; dipeptidyl arylamidase III; dipeptidyl aminopeptidase III |
| UniProt Protein Name: | Dipeptidyl peptidase 3 |
| UniProt Synonym Protein Names: | Dipeptidyl aminopeptidase III; Dipeptidyl arylamidase III; Dipeptidyl peptidase III; DPP III; Enkephalinase B |
| UniProt Gene Name: | DPP3 |
| UniProt Entry Name: | DPP3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using DPP3 antibody (CAB13390) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human liver damage using DPP3 antibody (CAB13390) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human gastric cancer using DPP3 antibody (CAB13390) at dilution of 1:100 (40x lens). |
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