Cell Death Antibodies 1

Anti-DPF2 Antibody (CAB13271)

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SKU:
CAB13271
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death

Description

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Antibody Name:Anti-DPF2 Antibody
Antibody SKU:CAB13271
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 126-391 of human DPF2 (NP_006259.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, NIH/3T3, Mouse brain, Rat pancreas
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 126-391 of human DPF2 (NP_006259.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:DPLE KRGA PDPR VDDD SLGE FPVT NSRA RKRI LEPD DFLD DLDD EDYE EDTP KRRG KGKS KGKG VGSA RKKL DASI LEDR DKPY ACDI CGKR YKNR PGLS YHYA HSHL AEEE GEDK EDSQ PPTP VSQR SEEQ KSKK GPDG LALP NNYC DFCL GDSK INKK TGQP EELV SCSD CGRS GHPS CLQF TPVM MAAV KTYR WQCI ECKC CNIC GTSE NDDQ LLFC DDCD RGYH MYCL TPSM SEPP EGSW SCHL CLDL LKEK ASIY QNQN SS
Gene ID:5977
Uniprot:Q92785
Cellular Location:Cytoplasm, Nucleus
Calculated MW:23kDa/44kDa
Observed MW:50kDa
Synonyms:DPF2, REQ, UBID4, ubi-d4
Background:The protein encoded by this gene is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors. It likely serves a regulatory role in rapid hematopoietic cell growth and turnover. This gene is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors.
UniProt Protein Function:requiem: May be a transcription factor required for the apoptosis response following survival factor withdrawal from myeloid cells. Might also have a role in the development and maturation of lymphoid cells. Belongs to the requiem/DPF family.
UniProt Protein Details:

Protein type:Apoptosis; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: centrosome; cytoplasm; intracellular membrane-bound organelle; nuclear chromatin; nucleoplasm

Molecular Function:protein binding; zinc ion binding

Biological Process: apoptosis; regulation of transcription, DNA-dependent; transcription, DNA-dependent

NCBI Summary:The protein encoded by this gene is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors. It likely serves a regulatory role in rapid hematopoietic cell growth and turnover. This gene is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors. [provided by RefSeq, Jul 2008]
UniProt Code:Q92785
NCBI GenInfo Identifier:2842711
NCBI Gene ID:5977
NCBI Accession:Q92785.2
UniProt Secondary Accession:Q92785,A8K7C9, B4DT58,
UniProt Related Accession:Q92785
Molecular Weight:23,599 Da
NCBI Full Name:Zinc finger protein ubi-d4
NCBI Synonym Full Names:double PHD fingers 2
NCBI Official Symbol:DPF2  
NCBI Official Synonym Symbols:REQ; UBID4; ubi-d4  
NCBI Protein Information:zinc finger protein ubi-d4
UniProt Protein Name:Zinc finger protein ubi-d4
UniProt Synonym Protein Names:Apoptosis response zinc finger protein; BRG1-associated factor 45D; BAF45D; D4, zinc and double PHD fingers family 2; Protein requiem
Protein Family:Zinc finger protein
UniProt Gene Name:DPF2  
UniProt Entry Name:REQU_HUMAN
Anti-DPF2 Antibody (CAB13271)Western blot analysis of extracts of various cell lines, using DPF2 antibody (CAB13271) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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