Neuroscience

Anti-DPF1 Antibody (CAB7349)

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SKU:
CAB7349
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Neuroscience

Description

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Antibody Name:Anti-DPF1 Antibody
Antibody SKU:CAB7349
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 295-414 of human DPF1 (NP_001128627.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 295-414 of human DPF1 (NP_001128627.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VIPN GYCD FCLG GSKK TGCP EDLI SCAD CGRS GHPS CLQF TVNM TAAV RTYR WQCI ECKS CSLC GTSE NDDQ LLFC DDCD RGYH MYCL SPPM AEPP EGSW SCHL CLRH LKEK ASAY ITLT
Gene ID:8193
Uniprot:Q92782
Cellular Location:Cytoplasm, Nucleus
Calculated MW:37kDa/42kDa/46kDa
Observed MW:Refer to figures
Synonyms:DPF1, BAF45b, NEUD4, neuro-d4
Background:
UniProt Protein Function:DPF1: May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Belongs to the requiem/DPF family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: cytoplasm

Molecular Function:zinc ion binding

Biological Process: nervous system development; transcription, DNA-dependent; regulation of transcription, DNA-dependent; apoptosis

UniProt Code:Q92782
NCBI GenInfo Identifier:313104100
NCBI Gene ID:8193
NCBI Accession:Q92782.2
UniProt Secondary Accession:Q92782,Q08AJ0, B3KSY8,
UniProt Related Accession:Q92782
Molecular Weight:380
NCBI Full Name:Zinc finger protein neuro-d4
NCBI Synonym Full Names:D4, zinc and double PHD fingers family 1
NCBI Official Symbol:DPF1  
NCBI Official Synonym Symbols:NEUD4; BAF45b; neuro-d4  
NCBI Protein Information:zinc finger protein neuro-d4; neuro-d4 homolog; BRG1-associated factor 45B
UniProt Protein Name:Zinc finger protein neuro-d4
UniProt Synonym Protein Names:BRG1-associated factor 45B; BAF45B; D4, zinc and double PHD fingers family 1
Protein Family:Zinc finger protein
UniProt Gene Name:DPF1  
UniProt Entry Name:DPF1_HUMAN
Anti-DPF1 Antibody (CAB7349)Immunofluorescence analysis of A549 cells using DPF1 antibody (CAB7349). Blue: DAPI for nuclear staining.
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