Metabolism Antibodies 2
Anti-DPEP1 Antibody (CAB6289)
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- SKU:
- CAB6289
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-DPEP1 Antibody |
| Antibody SKU: | CAB6289 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 17-385 of human DPEP1 (NP_001121613.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HT-29, HepG2 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 17-385 of human DPEP1 (NP_001121613.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | DFFR DEAE RIMR DSPV IDGH NDLP WQLL DMFN NRLQ DERA NLTT LAGT HTNI PKLR AGFV GGQF WSVY TPCD TQNK DAVR RTLE QMDV VHRM CRMY PETF LYVT SSAG IRQA FREG KVAS LIGV EGGH SIDS SLGV LRAL YQLG MRYL TLTH SCNT PWAD NWLV DTGD SEPQ SQGL SPFG QRVV KELN RLGV LIDL AHVS VATM KATL QLSR APVI FSHS SAYS VCAS RRNV PDDV LRLV KQTD SLVM VNFY NNYI SCTN KANL SQVA DHLD HIKE VAGA RAVG FGGD FDGV PRVP EGLE DVSK YPDL IAEL LRRN WTEA EVKG ALAD NLLR VFEA VEQA SNLT QAPE EEPI PLDQ LGGS CRTH YGYS S |
| Gene ID: | 1800 |
| Uniprot: | P16444 |
| Cellular Location: | Apical cell membrane, Cell projection, GPI-anchor, Lipid-anchor, microvillus membrane |
| Calculated MW: | 45kDa |
| Observed MW: | 46kDa |
| Synonyms: | DPEP1, MBD1, MDP, RDP |
| Background: | The protein encoded by this gene is a kidney membrane enzyme involved in the metabolism of glutathione and other similar proteins by dipeptide hydrolysis. The encoded protein is known to regulate leukotriene activity by catalyzing the conversion of leukotriene D4 to leukotriene E4. This protein uses zinc as a cofactor and acts as a disulfide-linked homodimer. Two transcript variants encoding the same protein have been found for this gene. |
| UniProt Protein Function: | DPEP1: Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity. Belongs to the peptidase M19 family. |
| UniProt Protein Details: | Protein type:EC 3.4.13.19; Membrane protein, GPI anchor; Protease Chromosomal Location of Human Ortholog: 16q24.3 Cellular Component: extracellular space; microvillus membrane; apical part of cell; apical plasma membrane; plasma membrane; nucleus; cell junction Molecular Function:protein binding; metalloexopeptidase activity; zinc ion binding; dipeptidyl-peptidase activity; caspase inhibitor activity Biological Process: glutathione metabolic process; xenobiotic metabolic process; arachidonic acid metabolic process; leukotriene metabolic process; negative regulation of caspase activity; homocysteine metabolic process; proteolysis; negative regulation of cell migration; antibiotic metabolic process; negative regulation of apoptosis |
| NCBI Summary: | The protein encoded by this gene is a kidney membrane enzyme involved in the metabolism of glutathione and other similar proteins by dipeptide hydrolysis. The encoded protein is known to regulate leukotriene activity by catalyzing the conversion of leukotriene D4 to leukotriene E4. This protein uses zinc as a cofactor and acts as a disulfide-linked homodimer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2012] |
| UniProt Code: | P16444 |
| NCBI GenInfo Identifier: | 92090943 |
| NCBI Gene ID: | 1800 |
| NCBI Accession: | P16444.3 |
| UniProt Secondary Accession: | P16444,Q96AK2, D3DX80, |
| UniProt Related Accession: | P16444 |
| Molecular Weight: | 411 |
| NCBI Full Name: | Dipeptidase 1 |
| NCBI Synonym Full Names: | dipeptidase 1 (renal) |
| NCBI Official Symbol: | DPEP1 |
| NCBI Official Synonym Symbols: | MDP; RDP; MBD1 |
| NCBI Protein Information: | dipeptidase 1; hRDP; renal dipeptidase; dehydropeptidase-I; microsomal dipeptidase |
| UniProt Protein Name: | Dipeptidase 1 |
| UniProt Synonym Protein Names: | Dehydropeptidase-I; Microsomal dipeptidase; Renal dipeptidase; hRDP |
| Protein Family: | Dipeptidase |
| UniProt Gene Name: | DPEP1 |
| UniProt Entry Name: | DPEP1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using DPEP1 antibody (CAB6289) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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