Anti-DOK1 Antibody (CAB19250)
- SKU:
- CAB19250
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- DOK1
- Synonyms:
- P62DOK
- Synonyms:
- pp62
- Synonyms:
- docking protein 1
- Research Area:
- Cell Biology
Description
| Product Name: | DOK1 Rabbit mAb |
| Product Code: | CAB19250 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | DOK1, P62DOK, pp62, docking protein 1 |
| Applications: | WB, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human DOK1. |
| Applications: | WB, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant protein of human DOK1. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 1796 |
| Uniprot: | Q99704 |
| Cellular Location: | Cytoplasm, Nucleus, perinuclear region |
| Calculated MW: | 65kDa |
| Observed MW: | Refer to figures |
| UniProt Protein Function: | DOK1: a docking protein that interacts with receptor tyrosine kinases. It is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Adaptor/scaffold Chromosomal Location of Human Ortholog: 2p13 Cellular Component: perinuclear region of cytoplasm; cytoplasm; cytosol; nucleus Molecular Function:protein binding; receptor signaling protein activity; insulin receptor binding Biological Process: cell surface receptor linked signal transduction; Ras protein signal transduction; insulin receptor signaling pathway; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway |
| NCBI Summary: | The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010] |
| UniProt Code: | Q99704 |
| NCBI GenInfo Identifier: | 17366642 |
| NCBI Gene ID: | 1796 |
| NCBI Accession: | Q99704.1 |
| UniProt Secondary Accession: | Q99704,O43204, Q53TY2, Q9UHG6, |
| UniProt Related Accession: | Q99704 |
| Molecular Weight: | 481 |
| NCBI Full Name: | Docking protein 1 |
| NCBI Synonym Full Names: | docking protein 1, 62kDa (downstream of tyrosine kinase 1) |
| NCBI Official Symbol: | DOK1 |
| NCBI Official Synonym Symbols: | P62DOK |
| NCBI Protein Information: | docking protein 1; pp62; p62(dok); Downstream of tyrosine kinase 1; docking protein 1 (downstream of tyrosine kinase 1) |
| UniProt Protein Name: | Docking protein 1 |
| UniProt Synonym Protein Names: | Downstream of tyrosine kinase 1; p62(dok); pp62 |
| Protein Family: | Docking protein |
| UniProt Gene Name: | DOK1 |
| UniProt Entry Name: | DOK1_HUMAN |
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