Anti-DNPH1 Antibody (CAB2382)

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SKU:
CAB2382
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
C6orf108
Synonyms:
RCL
Synonyms:
dJ330M21.3
Research Area:
Cell Biology

Description

Product Name:DNPH1 Rabbit mAb
Product Code:CAB2382
Size:20uL, 50uL, 100uL
Synonyms:C6orf108, RCL, dJ330M21.3
Applications:WB, IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human DNPH1.
Applications:WB, IF
Recommended Dilutions:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:293T, BT-474
Immunogen:A synthesized peptide derived from human DNPH1.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:10591
Uniprot:O43598
Calculated MW:21kDa
Observed MW:20KDa
UniProt Protein Function:DNPH1: Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5- phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'- monophosphates containing purine bases are preferred to those containing pyrimidine bases. Monomer and homodimer. Expression is induced by ETV1. Expressed at low levels in brain, colon, lung, peripheral blood leukocytes, placenta, small intestine, and thymus. Expressed at high levels in heart, kidney, liver, skeletal muscle and spleen. Overexpressed in a significant proportion of breast cancers. Belongs to the deoxyribonucleoside 5'-monophosphate N- glycosidase family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 3.2.2.-; Hydrolase

Chromosomal Location of Human Ortholog: 6p21.1

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function:protein homodimerization activity; nucleoside deoxyribosyltransferase activity

Biological Process: cell proliferation; epithelial cell differentiation; nucleoside metabolic process; nucleotide metabolic process; positive regulation of cell growth; deoxyribonucleoside monophosphate catabolic process

NCBI Summary:This gene was identified on the basis of its stimulation by c-Myc protein. The latter is a transcription factor that participates in the regulation of cell proliferation, differentiation, and apoptosis. The exact function of this gene is not known but studies in rat suggest a role in cellular proliferation and c-Myc-mediated transformation. Two alternative transcripts encoding different proteins have been described. [provided by RefSeq, Jul 2008]
UniProt Code:O43598
NCBI GenInfo Identifier:5454002
NCBI Gene ID:10591
NCBI Accession:NP_006434.1
UniProt Secondary Accession:O43598,Q80VJ3, O35820,
UniProt Related Accession:O43598
Molecular Weight:19,108 Da
NCBI Full Name:2'-deoxynucleoside 5'-phosphate N-hydrolase 1 isoform 1
NCBI Synonym Full Names:2'-deoxynucleoside 5'-phosphate N-hydrolase 1
NCBI Official Symbol:DNPH1  
NCBI Official Synonym Symbols:RCL; C6orf108; dJ330M21.3; RP3-330M21.3  
NCBI Protein Information:2'-deoxynucleoside 5'-phosphate N-hydrolase 1; putative c-Myc-responsive; c-Myc-responsive protein Rcl; deoxyribonucleoside 5'-monophosphate N-glycosidase
UniProt Protein Name:2'-deoxynucleoside 5'-phosphate N-hydrolase 1
UniProt Synonym Protein Names:c-Myc-responsive protein RCL
UniProt Gene Name:DNPH1  
UniProt Entry Name:DNPH1_HUMAN
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