Cell Biology Antibodies 13

Anti-DNPH1 Antibody (CAB17617)

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SKU:
CAB17617
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-DNPH1 Antibody
Antibody SKU:CAB17617
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-174 of human DNPH1 (NP_006434.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:293T, LO2, HeLa, Mouse heart, Mouse kidney, Rat kidney, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-174 of human DNPH1 (NP_006434.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAAA MVPG RSES WERG EPGR PALY FCGS IRGG REDR TLYE RIVS RLRR FGTV LTEH VAAA ELGA RGEE AAGG DRLI HEQD LEWL QQAD VVVA EVTQ PSLG VGYE LGRA VAFN KRIL CLFR PQSG RVLS AMIR GAAD GSRF QVWD YEEG EVEA LLDR YFEA DPPG QVAA SPDP TT
Gene ID:10591
Uniprot:O43598
Cellular Location:
Calculated MW:
Observed MW:23kDa
Anti-DNPH1 Antibody (CAB17617)Western blot - DNPH1 Polyclonal Antibody (CAB17617)
Synonyms:C6orf108, RCL, dJ330M21.3, DNPH1
Background:This gene was identified on the basis of its stimulation by c-Myc protein. The latter is a transcription factor that participates in the regulation of cell proliferation, differentiation, and apoptosis. The exact function of this gene is not known but studies in rat suggest a role in cellular proliferation and c-Myc-mediated transformation. Two alternative transcripts encoding different proteins have been described. [provided by RefSeq, Jul 2008]
UniProt Protein Function:DNPH1: Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5- phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'- monophosphates containing purine bases are preferred to those containing pyrimidine bases. Monomer and homodimer. Expression is induced by ETV1. Expressed at low levels in brain, colon, lung, peripheral blood leukocytes, placenta, small intestine, and thymus. Expressed at high levels in heart, kidney, liver, skeletal muscle and spleen. Overexpressed in a significant proportion of breast cancers. Belongs to the deoxyribonucleoside 5'-monophosphate N- glycosidase family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 3.2.2.-; Hydrolase

Chromosomal Location of Human Ortholog: 6p21.1

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function:protein homodimerization activity; nucleoside deoxyribosyltransferase activity

Biological Process: cell proliferation; epithelial cell differentiation; nucleoside metabolic process; nucleotide metabolic process; positive regulation of cell growth; deoxyribonucleoside monophosphate catabolic process

NCBI Summary:This gene was identified on the basis of its stimulation by c-Myc protein. The latter is a transcription factor that participates in the regulation of cell proliferation, differentiation, and apoptosis. The exact function of this gene is not known but studies in rat suggest a role in cellular proliferation and c-Myc-mediated transformation. Two alternative transcripts encoding different proteins have been described. [provided by RefSeq, Jul 2008]
UniProt Code:O43598
NCBI GenInfo Identifier:5454002
NCBI Gene ID:10591
NCBI Accession:NP_006434.1
UniProt Secondary Accession:O43598,Q80VJ3, O35820,
UniProt Related Accession:O43598
Molecular Weight:19,108 Da
NCBI Full Name:2'-deoxynucleoside 5'-phosphate N-hydrolase 1 isoform 1
NCBI Synonym Full Names:2'-deoxynucleoside 5'-phosphate N-hydrolase 1
NCBI Official Symbol:DNPH1  
NCBI Official Synonym Symbols:RCL; C6orf108; dJ330M21.3; RP3-330M21.3  
NCBI Protein Information:2'-deoxynucleoside 5'-phosphate N-hydrolase 1; putative c-Myc-responsive; c-Myc-responsive protein Rcl; deoxyribonucleoside 5'-monophosphate N-glycosidase
UniProt Protein Name:2'-deoxynucleoside 5'-phosphate N-hydrolase 1
UniProt Synonym Protein Names:c-Myc-responsive protein RCL
UniProt Gene Name:DNPH1  
UniProt Entry Name:DNPH1_HUMAN
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