Cell Biology Antibodies 5
Anti-DNM3 Antibody (CAB15148)
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- SKU:
- CAB15148
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-DNM3 Antibody |
| Antibody SKU: | CAB15148 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 410-555 of human DNM3 (NP_001265181.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | mouse brain, rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 410-555 of human DNM3 (NP_001265181.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | EAIV KKQI VKLK GPSL KSVD LVIQ ELIN TVKK CTKK LANF PRLC EETE RIVA NHIR EREG KTKD QVLL LIDI QVSY INTN HEDF IGFA NAQQ RSSQ VHKK TTVG NQVI RKGW LTIS NIGI MKGG SKGY WFVL TAES LSWY KDDE NI |
| Gene ID: | 26052 |
| Uniprot: | Q9UQ16 |
| Cellular Location: | Cytoplasm, cytoskeleton |
| Calculated MW: | 62kDa/96kDa/97kDa/98kDa |
| Observed MW: | 120kDa |
| Synonyms: | DNM3, Dyna III, DynaIII, dynamin-3 |
| Background: | This gene encodes a member of a family of guanosine triphosphate (GTP)-binding proteins that associate with microtubules and are involved in vesicular transport. The encoded protein functions in the development of megakaryocytes. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | DYN3: a microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Concentrates within dendritic spine tips of the postsynaptic compartment and interacts with mGluR5 and Homer. May play a role in dendritic spine morphogenesis and remodeling. |
| UniProt Protein Details: | Protein type:Mitochondrial; Vesicle; EC 3.6.5.5; Microtubule-binding; Motility/polarity/chemotaxis; Hydrolase; Motor Chromosomal Location of Human Ortholog: 1q24.3 Cellular Component: dendritic spine; perinuclear region of cytoplasm; postsynaptic density Molecular Function:GTPase activity; protein binding Biological Process: endocytosis; filopodium formation; synaptogenesis |
| NCBI Summary: | This gene encodes a member of a family of guanosine triphosphate (GTP)-binding proteins that associate with microtubules and are involved in vesicular transport. The encoded protein functions in the development of megakaryocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013] |
| UniProt Code: | Q9UQ16 |
| NCBI GenInfo Identifier: | 190358934 |
| NCBI Gene ID: | 26052 |
| NCBI Accession: | Q9UQ16.4 |
| UniProt Secondary Accession: | Q9UQ16,O14982, O95555, Q1MTM8, Q5W129, Q6P2G1, Q9H0P3 Q9H548, Q9NQ68, Q9NQN6, A9Z1Y1, |
| UniProt Related Accession: | Q9UQ16 |
| Molecular Weight: | 62,824 Da |
| NCBI Full Name: | Dynamin-3 |
| NCBI Synonym Full Names: | dynamin 3 |
| NCBI Official Symbol: | DNM3 |
| NCBI Official Synonym Symbols: | Dyna III |
| NCBI Protein Information: | dynamin-3 |
| UniProt Protein Name: | Dynamin-3 |
| UniProt Synonym Protein Names: | Dynamin, testicular; T-dynamin |
| Protein Family: | Dynamin |
| UniProt Gene Name: | DNM3 |
| UniProt Entry Name: | DYN3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using DNM3 antibody (CAB15148) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunofluorescence analysis of L929 cells using DNM3 Polyclonal Antibody (CAB15148) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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