Cell Biology Antibodies 15
Anti-DND1 Antibody (CAB18567)
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- SKU:
- CAB18567
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-DND1 Antibody |
| Antibody SKU: | CAB18567 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human DND1. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Rat |
| Positive Samples: |
| Immunogen: | Recombinant protein of human DND1. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 373863 |
| Uniprot: | Q8IYX4 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | RBMS4, DND1 |
| Background: |
| UniProt Protein Function: | DND1: RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells. Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3' untranslated region (3'-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival. However, does not seem to be essential for PGC migration. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 5q31.3 Cellular Component: cytoplasm; nucleus Molecular Function:AU-rich element binding; miRNA binding |
| NCBI Summary: | This gene encodes a protein that binds to microRNA-targeting sequences of mRNAs, inhibiting microRNA-mediated repression. Reduced expression of this gene has been implicated in tongue squamous cell carcinoma. Two pseudogenes of this gene are located on the long arm of chromosome 17. [provided by RefSeq, Dec 2010] |
| UniProt Code: | Q8IYX4 |
| NCBI GenInfo Identifier: | 60389799 |
| NCBI Gene ID: | 373863 |
| NCBI Accession: | Q8IYX4.1 |
| UniProt Related Accession: | Q8IYX4 |
| Molecular Weight: | 38,687 Da |
| NCBI Full Name: | Dead end protein homolog 1 |
| NCBI Synonym Full Names: | DND microRNA-mediated repression inhibitor 1 |
| NCBI Official Symbol: | DND1 |
| NCBI Official Synonym Symbols: | RBMS4 |
| NCBI Protein Information: | dead end protein homolog 1 |
| UniProt Protein Name: | Dead end protein homolog 1 |
| UniProt Synonym Protein Names: | RNA-binding motif, single-stranded-interacting protein 4 |
| Protein Family: | Dead end protein |
| UniProt Gene Name: | DND1 |
| UniProt Entry Name: | DND1_HUMAN |
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