Cell Death Antibodies 1
Anti-DNASE1L3 Antibody (CAB15608)
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- SKU:
- CAB15608
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-DNASE1L3 Antibody |
| Antibody SKU: | CAB15608 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-281 of human DNASE1L3 (NP_004935.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse spleen |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-281 of human DNASE1L3 (NP_004935.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MRIC SFNV RSFG ESKQ EDKN AMDV IVKV IKRC DIIL VMEI KDSN NRIC PILM EKLN RNSR RGIT YNYV ISSR LGRN TYKE QYAF LYKE KLVS VKRS YHYH DYQD GDAD VFSR EPFV VWFQ SPHT AVKD FVII PLHT TPET SVKE IDEL VEVY TDVK HRWK AENF IFMG DFNA GCSY VPKK AWKN IRLR TDPR FVWL IGDQ EDTT VKKS TNCA YDRI VLRG QEIV SSVV PKSN SVFD FQKA YKLT EEEA LDVS DHFP VEFK L |
| Gene ID: | 1776 |
| Uniprot: | Q13609 |
| Cellular Location: | |
| Calculated MW: | 31kDa/35kDa |
| Observed MW: | 31kDa |
| Synonyms: | DNASE1L3, DHP2, DNAS1L3, LSD, SLEB16 |
| Background: | This gene encodes a member of the deoxyribonuclease I family. The encoded protein hydrolyzes DNA, is not inhibited by actin, and mediates the breakdown of DNA during apoptosis. Mutations in this gene are a cause of systemic lupus erythematosus-16. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| UniProt Protein Function: | DNASE1L3: Has DNA hydrolytic activity. Does not bind to actin. Cleaves chromatin DNA to nucleosomal units. Defects in DNASE1L3 are the cause of systemic lupus erythematosus type 16 (SLEB16). A rare autosomal recessive form of systemic lupus erythematosus with childhood onset, characterized by high frequency of anti-neutrophil cytoplasmic antibodies and lupus nephritis. Systemic lupus erythematosus is a chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Belongs to the DNase I family. |
| UniProt Protein Details: | Protein type:EC 3.1.21.-; Secreted, signal peptide; Calcium-binding; Secreted; Deoxyribonuclease; Apoptosis Chromosomal Location of Human Ortholog: 3p14.3 Cellular Component: nucleus Molecular Function:endodeoxyribonuclease activity, producing 5'-phosphomonoesters; DNA binding; deoxyribonuclease activity; calcium ion binding; endodeoxyribonuclease activity Biological Process: DNA fragmentation during apoptosis; DNA metabolic process Disease: Systemic Lupus Erythematosus 16 |
| NCBI Summary: | This gene encodes a member of the deoxyribonuclease I family. The encoded protein hydrolyzes DNA, is not inhibited by actin, and mediates the breakdown of DNA during apoptosis. Mutations in this gene are a cause of systemic lupus erythematosus-16. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012] |
| UniProt Code: | Q13609 |
| NCBI GenInfo Identifier: | 2494173 |
| NCBI Gene ID: | 1776 |
| NCBI Accession: | Q13609.1 |
| UniProt Related Accession: | Q13609 |
| Molecular Weight: | 33.4 kDa |
| NCBI Full Name: | Deoxyribonuclease gamma |
| NCBI Synonym Full Names: | deoxyribonuclease 1 like 3 |
| NCBI Official Symbol: | DNASE1L3 |
| NCBI Official Synonym Symbols: | LSD; DHP2; SLEB16; DNAS1L3 |
| NCBI Protein Information: | deoxyribonuclease gamma |
| UniProt Protein Name: | Deoxyribonuclease gamma |
| UniProt Synonym Protein Names: | DNase I homolog protein DHP2; Deoxyribonuclease I-like 3; DNase I-like 3; Liver and spleen DNase; LS-DNase; LSD |
| Protein Family: | Deoxyribonuclease |
| UniProt Gene Name: | DNASE1L3 |
| UniProt Entry Name: | DNSL3_HUMAN |
 | Western blot analysis of extracts of mouse spleen, using DNASE1L3 antibody (CAB15608) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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