Cell Biology Antibodies 2
Anti-DNAL4 Antibody (CAB12208)
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- SKU:
- CAB12208
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-DNAL4 Antibody |
| Antibody SKU: | CAB12208 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-105 of human DNAL4 (NP_005731.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse testis, Rat testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-105 of human DNAL4 (NP_005731.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MGET EGKK DEAD YKRL QTFP LVRH SDMP EEMR VETM ELCV TACE KFSN NNES AAKM IKET MDKK FGSS WHVV IGEG FGFE ITHE VKNL LYLY FGGT LAVC VWKC S |
| Gene ID: | 10126 |
| Uniprot: | O96015 |
| Cellular Location: | Cytoplasm, cilium axoneme, cytoskeleton |
| Calculated MW: | 12kDa |
| Observed MW: | 12kDa |
| Synonyms: | DNAL4, MRMV3, PIG27 |
| Background: | This gene encodes an axonemal dynein light chain which functions as a component of the outer dynein arms complex. This complex acts as the molecular motor that provides the force to move cilia in an ATP-dependent manner. The encoded protein is expressed in tissues with motile cilia or flagella and may be involved in the movement of sperm flagella. |
| UniProt Protein Function: | DNAL4: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity. Belongs to the dynein light chain family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 22q13.1 Cellular Component: plasma membrane Molecular Function:microtubule motor activity; protein binding Biological Process: microtubule-based movement Disease: Mirror Movements 3 |
| NCBI Summary: | This gene encodes an axonemal dynein light chain which functions as a component of the outer dynein arms complex. This complex acts as the molecular motor that provides the force to move cilia in an ATP-dependent manner. The encoded protein is expressed in tissues with motile cilia or flagella and may be involved in the movement of sperm flagella. [provided by RefSeq, Dec 2014] |
| UniProt Code: | O96015 |
| NCBI GenInfo Identifier: | 21542026 |
| NCBI Gene ID: | 10126 |
| NCBI Accession: | O96015.1 |
| UniProt Secondary Accession: | O96015,Q6FGB2, Q6FGD0, |
| UniProt Related Accession: | O96015 |
| Molecular Weight: | 12kDa |
| NCBI Full Name: | Dynein light chain 4, axonemal |
| NCBI Synonym Full Names: | dynein axonemal light chain 4 |
| NCBI Official Symbol: | DNAL4 |
| NCBI Official Synonym Symbols: | MRMV3; PIG27 |
| NCBI Protein Information: | dynein light chain 4, axonemal |
| UniProt Protein Name: | Dynein light chain 4, axonemal |
| Protein Family: | Dynein |
| UniProt Gene Name: | DNAL4 |
 | Western blot analysis of extracts of various cell lines, using DNAL4 antibody (CAB12208) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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