Cell Biology Antibodies 8

Anti-DNAJC7 Antibody (CAB2780)

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SKU:
CAB2780
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-DNAJC7 Antibody
Antibody SKU:CAB2780
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 230-380 of human DNAJC7 (NP_003306.3).
Application:WB
Recommended Dilution:WB 1:1000 - 1:2000
Reactivity:Human
Positive Samples:A-431, 293T, K-562
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 230-380 of human DNAJC7 (NP_003306.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VQFF VQAL RMAP DHEK ACIA CRNA KALK AKKE DGNK AFKE GNYK LAYE LYTE ALGI DPNN IKTN AKLY CNRG TVNS KLRK LDDA IEDC TNAV KLDD TYIK AYLR RAQC YMDT EQYE EAVR DYEK VYQT EKTK EHKQ LLKN AQLE LKKS KRK
Gene ID:7266
Uniprot:Q99615
Cellular Location:Cytoplasm, Nucleus, cytoskeleton
Calculated MW:50kDa/56kDa
Observed MW:60kDa
Synonyms:DNAJC7, DJ11, DJC7, TPR2, TTC2
Background:This gene encodes a member of the DNAJ heat shock protein 40 family of proteins that is characterized by two N-terminal tetratricopeptide repeat domains and a C-terminal DNAJ domain. This protein binds the chaperone proteins heat shock proteins 70 and 90 in an ATP-dependent manner and may function as a co-chaperone. Pseudogenes of this gene are found on chromosomes 1 and 6. Alternate splicing results in multiple transcript variants.
UniProt Protein Function:DNAJC7: a co-chaperone protein that binds both Hsp70 and Hsp90 through its TPR domains. Its DnaJ domain stimulates ATP hydrolysis and polypeptide binding by Hsp70. Interacts with the proapoptotic and cell-cycle checkpoint protein Rad9. Rad9 transiently dissociates from Tpr2 following heat-shock or UV treatments.
UniProt Protein Details:

Protein type:Chaperone

Chromosomal Location of Human Ortholog: 17q21.2

Cellular Component: nucleoplasm; cytoskeleton; membrane; cytoplasm

Molecular Function:protein binding; heat shock protein binding

Biological Process: protein folding

NCBI Summary:This gene encodes a member of the DNAJ heat shock protein 40 family of proteins that is characterized by two N-terminal tetratricopeptide repeat domains and a C-terminal DNAJ domain. This protein binds the chaperone proteins heat shock proteins 70 and 90 in an ATP-dependent manner and may function as a co-chaperone. Pseudogenes of this gene are found on chromosomes 1 and 6. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]
UniProt Code:Q99615
NCBI GenInfo Identifier:46397879
NCBI Gene ID:7266
NCBI Accession:Q99615.2
UniProt Related Accession:Q99615
Molecular Weight:60kDa
NCBI Full Name:DnaJ homolog subfamily C member 7
NCBI Synonym Full Names:DnaJ heat shock protein family (Hsp40) member C7
NCBI Official Symbol:DNAJC7  
NCBI Official Synonym Symbols:DJ11; DJC7; TPR2; TTC2  
NCBI Protein Information:dnaJ homolog subfamily C member 7
UniProt Protein Name:DnaJ homolog subfamily C member 7
UniProt Synonym Protein Names:Tetratricopeptide repeat protein 2; TPR repeat protein 2
Protein Family:DnaJ homolog subfamily
UniProt Gene Name:DNAJC7  
UniProt Entry Name:DNJC7_HUMAN
Anti-DNAJC7 Antibody (CAB2780)Western blot analysis of extracts of various cell lines, using DNAJC7 antibody (CAB2780) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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