Anti-DNA Ligase I Antibody (CAB9301)
- SKU:
- CAB9301
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Cycle
Description
| Product Name: | DNA Ligase I Rabbit mAb |
| Product Code: | CAB9301 |
| Size: | 20uL, 50uL, 100uL |
| Applications: | WB, IHC, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human DNA Ligase I |
| Applications: | WB, IHC, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Jurkat |
| Immunogen: | A synthesized peptide derived from human DNA Ligase I |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 3978 |
| Uniprot: | P18858 |
| Calculated MW: | 140kDa |
| Observed MW: | 130KDa |
| UniProt Protein Function: | LIG1: is an enzyme that functions in DNA replication and the base excision repair process. Mutations leading to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. |
| UniProt Protein Details: | Protein type:Ligase; EC 6.5.1.1; DNA repair, damage Chromosomal Location of Human Ortholog: 19q13.2-q13.3 Cellular Component: nucleoplasm; Golgi apparatus; intracellular membrane-bound organelle; mitochondrion; chromosome; nucleus Molecular Function:DNA binding; DNA ligase activity; metal ion binding; DNA ligase (ATP) activity; ATP binding Biological Process: anatomical structure morphogenesis; mismatch repair; V(D)J recombination; DNA strand elongation during DNA replication; DNA repair; lagging strand elongation; double-strand break repair via homologous recombination; double-strand break repair via nonhomologous end joining; telomere maintenance via semi-conservative replication; response to hydrogen peroxide; base-excision repair; nucleotide-excision repair; cell division; transcription-coupled nucleotide-excision repair; double-strand break repair; telomere maintenance via recombination; DNA ligation during DNA repair; nucleotide-excision repair, DNA gap filling; mitotic cell cycle; telomere maintenance; DNA metabolic process |
| NCBI Summary: | This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] |
| UniProt Code: | P18858 |
| NCBI GenInfo Identifier: | 118773 |
| NCBI Gene ID: | 3978 |
| NCBI Accession: | P18858.1 |
| UniProt Related Accession: | P18858 |
| Molecular Weight: | Predicted Band Size: 102kDa |
| NCBI Full Name: | DNA ligase 1 |
| NCBI Synonym Full Names: | DNA ligase 1 |
| NCBI Official Symbol: | LIG1 |
| NCBI Protein Information: | DNA ligase 1 |
| UniProt Protein Name: | DNA ligase 1 |
| UniProt Synonym Protein Names: | DNA ligase I; Polydeoxyribonucleotide synthase [ATP] 1 |
| UniProt Gene Name: | LIG1 |
| UniProt Entry Name: | DNLI1_HUMAN |
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