Cell Cycle Antibodies 1
Anti-DMC1 Antibody (CAB4491)
- SKU:
- CAB4491
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- DMC1
- Synonyms:
- DMC1H
- Synonyms:
- LIM15
- Synonyms:
- dJ199H16.1
- Research Area:
- Cell Cycle
Description
| Product Name: | DMC1 Rabbit pAb |
| Product Code: | CAB4491 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | DMC1, DMC1H, LIM15, dJ199H16.1 |
| Applications: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human DMC1 (NP_008999.2). |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Mouse testis, Rat testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human DMC1 (NP_008999.2). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MKED QVVA EEPG FQDE EESL FQDI DLLQ KHGI NVAD IKKL KSVG ICTI KGIQ MTTR RALC NVKG LSEA KVDK IKEA ANKL IEPG FLTA FEYS EKRK MVFH ITTG SQEF DKLL GGGI ESMA ITEA FGEF RTGK TQLS HTLC VTAQ LPGA GGYP GGKI IFID TENT FRPD RLRD IADR FNVD HDAV LDNV LYAR AYTS EHQM ELLD YVAA KFHE EAGI FKLL IIDS IMAL FRVD FSGR GELA ERQQ KLAQ MLSR LQKI SEEY |
| Gene ID: | 11144 |
| Uniprot: | Q14565 |
| Cellular Location: | Chromosome, Nucleus |
| Calculated MW: | 31kDa/37kDa |
| Observed MW: | 38KDa |
| UniProt Protein Function: | DMC1: May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks. Belongs to the RecA family. DMC1 subfamily. |
| UniProt Protein Details: | Protein type:DNA repair, damage; Cell development/differentiation; Cell cycle regulation Chromosomal Location of Human Ortholog: 22q13.1 Cellular Component: chromosome; nucleoplasm; nucleus Molecular Function:DNA binding; DNA-dependent ATPase activity; double-stranded DNA binding; endodeoxyribonuclease activity; four-way junction DNA binding; protein binding; recombinase activity; single-stranded DNA binding Biological Process: DNA recombinase assembly; female gamete generation; meiosis; mitotic recombination; response to ionizing radiation; spermatogenesis; strand invasion |
| NCBI Summary: | This gene encodes a member of the superfamily of recombinases (also called DNA strand-exchange proteins). Recombinases are important for repairing double-strand DNA breaks during mitosis and meiosis. This protein, which is evolutionarily conserved, is reported to be essential for meiotic homologous recombination and may thus play an important role in generating diversity of genetic information. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013] |
| UniProt Code: | Q14565 |
| NCBI GenInfo Identifier: | 13878923 |
| NCBI Gene ID: | 11144 |
| NCBI Accession: | Q14565.2 |
| UniProt Secondary Accession: | Q14565,Q08AI1, Q99498, Q9UH11, A8K9A2, B4DMW6, |
| UniProt Related Accession: | Q14565 |
| Molecular Weight: | 31,559 Da |
| NCBI Full Name: | Meiotic recombination protein DMC1/LIM15 homolog |
| NCBI Synonym Full Names: | DNA meiotic recombinase 1 |
| NCBI Official Symbol: | DMC1 |
| NCBI Official Synonym Symbols: | DMC1H; LIM15; dJ199H16.1 |
| NCBI Protein Information: | meiotic recombination protein DMC1/LIM15 homolog |
| UniProt Protein Name: | Meiotic recombination protein DMC1/LIM15 homolog |
| Protein Family: | Meiotic recombination protein |
| UniProt Gene Name: | DMC1 |
| UniProt Entry Name: | DMC1_HUMAN |
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