Cell Cycle Antibodies 1

Anti-DMC1 Antibody (CAB4491)

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SKU:
CAB4491
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
DMC1
Synonyms:
DMC1H
Synonyms:
LIM15
Synonyms:
dJ199H16.1
Research Area:
Cell Cycle

Description

Product Name:DMC1 Rabbit pAb
Product Code:CAB4491
Size:20uL, 50uL, 100uL
Synonyms:DMC1, DMC1H, LIM15, dJ199H16.1
Applications:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human DMC1 (NP_008999.2).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:Mouse testis, Rat testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human DMC1 (NP_008999.2).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MKED QVVA EEPG FQDE EESL FQDI DLLQ KHGI NVAD IKKL KSVG ICTI KGIQ MTTR RALC NVKG LSEA KVDK IKEA ANKL IEPG FLTA FEYS EKRK MVFH ITTG SQEF DKLL GGGI ESMA ITEA FGEF RTGK TQLS HTLC VTAQ LPGA GGYP GGKI IFID TENT FRPD RLRD IADR FNVD HDAV LDNV LYAR AYTS EHQM ELLD YVAA KFHE EAGI FKLL IIDS IMAL FRVD FSGR GELA ERQQ KLAQ MLSR LQKI SEEY
Gene ID:11144
Uniprot:Q14565
Cellular Location:Chromosome, Nucleus
Calculated MW:31kDa/37kDa
Observed MW:38KDa
UniProt Protein Function:DMC1: May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks. Belongs to the RecA family. DMC1 subfamily.
UniProt Protein Details:

Protein type:DNA repair, damage; Cell development/differentiation; Cell cycle regulation

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: chromosome; nucleoplasm; nucleus

Molecular Function:DNA binding; DNA-dependent ATPase activity; double-stranded DNA binding; endodeoxyribonuclease activity; four-way junction DNA binding; protein binding; recombinase activity; single-stranded DNA binding

Biological Process: DNA recombinase assembly; female gamete generation; meiosis; mitotic recombination; response to ionizing radiation; spermatogenesis; strand invasion

NCBI Summary:This gene encodes a member of the superfamily of recombinases (also called DNA strand-exchange proteins). Recombinases are important for repairing double-strand DNA breaks during mitosis and meiosis. This protein, which is evolutionarily conserved, is reported to be essential for meiotic homologous recombination and may thus play an important role in generating diversity of genetic information. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
UniProt Code:Q14565
NCBI GenInfo Identifier:13878923
NCBI Gene ID:11144
NCBI Accession:Q14565.2
UniProt Secondary Accession:Q14565,Q08AI1, Q99498, Q9UH11, A8K9A2, B4DMW6,
UniProt Related Accession:Q14565
Molecular Weight:31,559 Da
NCBI Full Name:Meiotic recombination protein DMC1/LIM15 homolog
NCBI Synonym Full Names:DNA meiotic recombinase 1
NCBI Official Symbol:DMC1  
NCBI Official Synonym Symbols:DMC1H; LIM15; dJ199H16.1  
NCBI Protein Information:meiotic recombination protein DMC1/LIM15 homolog
UniProt Protein Name:Meiotic recombination protein DMC1/LIM15 homolog
Protein Family:Meiotic recombination protein
UniProt Gene Name:DMC1  
UniProt Entry Name:DMC1_HUMAN
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