Cell Biology Antibodies 10

Anti-DLX3 Antibody (CAB6902)

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SKU:
CAB6902
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-DLX3 Antibody
Antibody SKU:CAB6902
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human DLX3 (NP_005211.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse liver, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human DLX3 (NP_005211.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MSGS FDRK LSSI LTDI SSSL SCHA GSKD SPTL PESS VTDL GYYS APQH DYYS GQPY GQTV NPYT YHHQ FNLN GLAG TGAY SPKS EYTY GASY RQYG AYRE QPLP AQDP VSVK EEPE AEVR
Gene ID:1747
Uniprot:O60479
Cellular Location:Nucleus
Calculated MW:31kDa
Observed MW:32kDa/35kDa
Synonyms:DLX3, AI4, TDO
Background:Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. Trichodentoosseous syndrome (TDO), an autosomal dominant condition, has been correlated with DLX3 gene mutation. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 17. Mutations in this gene have been associated with the autosomal dominant conditions trichodentoosseous syndrome and amelogenesis imperfecta with taurodontism.
UniProt Protein Function:DLX3: Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis. Defects in DLX3 are a cause of trichodentoosseous syndrome (TDO). TDO is an autosomal dominant syndrome characterized by enamel hypoplasia and hypocalcification with associated strikingly curly hair. Defects in DLX3 are the cause of amelogenesis imperfecta type 4 (AI4); also known as amelogenesis imperfecta hypomaturation-hypoplastic type with taurodontism. AI4 is an autosomal dominant defect of enamel formation associated with enlarged pulp chambers. Belongs to the distal-less homeobox family.
UniProt Protein Details:

Protein type:DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 17q21.33

Molecular Function:transcription factor activity

Disease: Amelogenesis Imperfecta, Type Iv; Trichodentoosseous Syndrome

NCBI Summary:Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. Trichodentoosseous syndrome (TDO), an autosomal dominant condition, has been correlated with DLX3 gene mutation. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 17. Mutations in this gene have been associated with the autosomal dominant conditions trichodentoosseous syndrome and amelogenesis imperfecta with taurodontism. [provided by RefSeq, Jul 2008]
UniProt Code:O60479
NCBI GenInfo Identifier:3913487
NCBI Gene ID:1747
NCBI Accession:O60479.1
UniProt Secondary Accession:O60479,B3KQL6,
UniProt Related Accession:O60479
Molecular Weight:31,738 Da
NCBI Full Name:Homeobox protein DLX-3
NCBI Synonym Full Names:distal-less homeobox 3
NCBI Official Symbol:DLX3  
NCBI Official Synonym Symbols:AI4; TDO  
NCBI Protein Information:homeobox protein DLX-3
UniProt Protein Name:Homeobox protein DLX-3
Protein Family:Distal-less-like protein
UniProt Gene Name:DLX3  
Anti-DLX3 Antibody (CAB6902)Western blot analysis of extracts of various cell lines, using DLX3 Antibody (CAB6902) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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