Cell Biology Antibodies 4
Anti-DLX3 Antibody (CAB13972)
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- SKU:
- CAB13972
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-DLX3 Antibody |
| Antibody SKU: | CAB13972 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human DLX3 (NP_005211.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human DLX3 (NP_005211.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSGS FDRK LSSI LTDI SSSL SCHA GSKD SPTL PESS VTDL GYYS APQH DYYS GQPY GQTV NPYT YHHQ FNLN GLAG TGAY SPKS EYTY GASY RQYG AYRE QPLP AQDP VSVK EEPE AEVR |
| Gene ID: | 1747 |
| Uniprot: | O60479 |
| Cellular Location: | Nucleus |
| Calculated MW: | 31kDa |
| Observed MW: | Refer to figures |
| Synonyms: | DLX3, AI4, TDO |
| Background: | Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. Trichodentoosseous syndrome (TDO), an autosomal dominant condition, has been correlated with DLX3 gene mutation. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 17. Mutations in this gene have been associated with the autosomal dominant conditions trichodentoosseous syndrome and amelogenesis imperfecta with taurodontism. |
| UniProt Protein Function: | DLX3: Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis. Defects in DLX3 are a cause of trichodentoosseous syndrome (TDO). TDO is an autosomal dominant syndrome characterized by enamel hypoplasia and hypocalcification with associated strikingly curly hair. Defects in DLX3 are the cause of amelogenesis imperfecta type 4 (AI4); also known as amelogenesis imperfecta hypomaturation-hypoplastic type with taurodontism. AI4 is an autosomal dominant defect of enamel formation associated with enlarged pulp chambers. Belongs to the distal-less homeobox family. |
| UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 17q21.33 Molecular Function:transcription factor activity Disease: Amelogenesis Imperfecta, Type Iv; Trichodentoosseous Syndrome |
| NCBI Summary: | Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. Trichodentoosseous syndrome (TDO), an autosomal dominant condition, has been correlated with DLX3 gene mutation. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 17. Mutations in this gene have been associated with the autosomal dominant conditions trichodentoosseous syndrome and amelogenesis imperfecta with taurodontism. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O60479 |
| NCBI GenInfo Identifier: | 3913487 |
| NCBI Gene ID: | 1747 |
| NCBI Accession: | O60479.1 |
| UniProt Secondary Accession: | O60479,B3KQL6, |
| UniProt Related Accession: | O60479 |
| Molecular Weight: | 31,738 Da |
| NCBI Full Name: | Homeobox protein DLX-3 |
| NCBI Synonym Full Names: | distal-less homeobox 3 |
| NCBI Official Symbol: | DLX3 |
| NCBI Official Synonym Symbols: | AI4; TDO |
| NCBI Protein Information: | homeobox protein DLX-3 |
| UniProt Protein Name: | Homeobox protein DLX-3 |
| Protein Family: | Distal-less-like protein |
| UniProt Gene Name: | DLX3 |
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