Metabolism Antibodies 2

Anti-DLST Antibody (CAB6901)

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SKU:
CAB6901
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism

Description

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Antibody Name:Anti-DLST Antibody
Antibody SKU:CAB6901
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human DLST (NP_001924.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:MCF7, SKOV3, HeLa, HepG2, Mouse liver, Mouse kidney, Mouse heart, Rat kidney, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human DLST (NP_001924.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MLSR SRCV SRAF SRSL SAFQ KGNC PLGR RSLP GVSL CQGP GYPN SRKV VINN SVFS VRFF RTTA VCKD DLVT VKTP AFAE SVTE GDVR WEKA VGDT VAED EVVC EIET DKTS VQVP SPAN GVIE ALLV PDGG KVEG GTPL FTLR KTGA APAK AKPA EAPA AAAP KAEP TAAA VPPP AAPI PTQM PPVP SPSQ PPSG KPVS AVKP TVAP PLAE PGAG KGLR SEHR EKMN RMRQ RIAQ RLKE AQNT CAML TTFN EIDM SNIQ EMRA RHKE AFLK KHNL KLGF MSAF VKAS AF
Gene ID:1743
Uniprot:P36957
Cellular Location:Mitochondrion
Calculated MW:39kDa/48kDa
Observed MW:49kDa
Synonyms:DLST, DLTS
Background:This gene encodes a mitochondrial protein that belongs to the 2-oxoacid dehydrogenase family. This protein is one of the three components (the E2 component) of the 2-oxoglutarate dehydrogenase complex that catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). Alternatively spliced transcript variants have been found for this gene.
UniProt Protein Function:DLST: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3). Forms a 24-polypeptide structural core with octahedral symmetry. Belongs to the 2-oxoacid dehydrogenase family.
UniProt Protein Details:

Protein type:Amino Acid Metabolism - lysine degradation; Transferase; Carbohydrate Metabolism - citrate (TCA) cycle; EC 2.3.1.61; Mitochondrial

Chromosomal Location of Human Ortholog: 14q24.3

Cellular Component: membrane; mitochondrial matrix; oxoglutarate dehydrogenase complex; nucleus

Molecular Function:dihydrolipoyllysine-residue succinyltransferase activity

Biological Process: cellular metabolic process; generation of precursor metabolites and energy; tricarboxylic acid cycle; L-lysine catabolic process to acetyl-CoA via saccharopine; lysine catabolic process

NCBI Summary:This gene encodes a mitochondrial protein that belongs to the 2-oxoacid dehydrogenase family. This protein is one of the three components (the E2 component) of the 2-oxoglutarate dehydrogenase complex that catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]
UniProt Code:P36957
NCBI GenInfo Identifier:317373578
NCBI Gene ID:1743
NCBI Accession:P36957.4
UniProt Secondary Accession:P36957,Q7LDY7, Q9BQ32,
UniProt Related Accession:P36957
Molecular Weight:48,755 Da
NCBI Full Name:Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
NCBI Synonym Full Names:dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
NCBI Official Symbol:DLST  
NCBI Official Synonym Symbols:DLTS  
NCBI Protein Information:dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial; E2K; OGDC-E2
UniProt Protein Name:Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
UniProt Synonym Protein Names:2-oxoglutarate dehydrogenase complex component E2; OGDC-E2; Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2K
Protein Family:Serine transporter
UniProt Gene Name:DLST  
UniProt Entry Name:ODO2_HUMAN
Anti-DLST Antibody (CAB6901)Western blot analysis of extracts of various cell lines, using DLST antibody (CAB6901) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
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