Cell Biology Antibodies 14

Anti-DLL3 Antibody (CAB18108)

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SKU:
CAB18108
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-DLL3 Antibody
Antibody SKU:CAB18108
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 27-250 of human DLL3 (NP_058637.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 27-250 of human DLL3 (NP_058637.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:AGVF ELQI HSFG PGPG PGAP RSPC SARL PCRL FFRV CLKP GLSE EAAE SPCA LGAA LSAR GPVY TEQP GAPA PDLP LPDG LLQV PFRD AWPG TFSF IIET WREE LGDQ IGGP AWSL LARV AGRR RLAA GGPW ARDI QRAG AWEL RFSY RARC EPPA VGTA CTRL CRPR SAPS RCGP GLRP CAPL EDEC EAPL VCRA GCSP EHGF CEQP GECR CLEG WTGP LCTV
Gene ID:10683
Uniprot:Q9NYJ7
Cellular Location:
Calculated MW:
Observed MW:Refer to figures
Synonyms:SCDO1, DLL3
Background:
UniProt Protein Function:DLL3: Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. Can bind and activate Notch-1 or another Notch receptor.
UniProt Protein Details:

Protein type:Cell development/differentiation; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13

Cellular Component: integral to membrane

Molecular Function:Notch binding

Biological Process: compartment specification; paraxial mesoderm development; Notch signaling pathway; somitogenesis; skeletal development; negative regulation of neurogenesis

Disease: Spondylocostal Dysostosis 1, Autosomal Recessive

NCBI Summary:This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q9NYJ7
NCBI GenInfo Identifier:45243561
NCBI Gene ID:10683
NCBI Accession:NP_982353.1
UniProt Secondary Accession:Q9NYJ7,Q8NBS4, E9PFG2,
UniProt Related Accession:Q9NYJ7
Molecular Weight:
NCBI Full Name:delta-like protein 3 isoform 2
NCBI Synonym Full Names:delta-like 3 (Drosophila)
NCBI Official Symbol:DLL3  
NCBI Official Synonym Symbols:SCDO1  
NCBI Protein Information:delta-like protein 3; delta3; drosophila Delta homolog 3
UniProt Protein Name:Delta-like protein 3
UniProt Synonym Protein Names:Drosophila Delta homolog 3
Protein Family:Delta-like protein
UniProt Gene Name:DLL3  
UniProt Entry Name:DLL3_HUMAN
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