Cell Biology Antibodies 10
Anti-DLK1 Antibody (CAB6578)
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- SKU:
- CAB6578
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-DLK1 Antibody |
| Antibody SKU: | CAB6578 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 83-383 of human DLK1 (NP_003827.3). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Mouse heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 83-383 of human DLK1 (NP_003827.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ELCD RDVR ACSS APCA NNGT CVSL DDGL YECS CAPG YSGK DCQK KDGP CVIN GSPC QHGG TCVD DEGR ASHA SCLC PPGF SGNF CEIV ANSC TPNP CEND GVCT DIGG DFRC RCPA GFID KTCS RPVT NCAS SPCQ NGGT CLQH TQVS YECL CKPE FTGL TCVK KRAL SPQQ VTRL PSGY GLAY RLTP GVHE LPVQ QPEH RILK VSMK ELNK KTPL LTEG QAIC FTIL GVLT SLVV LGTV GIVF LNKC ETWV SNLR YNHM LRKK KNLL LQYN SGED LAVN IIFP EKID MTTF SKEA GDEE I |
| Gene ID: | 8788 |
| Uniprot: | P80370 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 33kDa/41kDa |
| Observed MW: | 45KDa |
| Synonyms: | DLK1, DLK, DLK-1, Delta1, FA1, PREF1, Pref-1, ZOG, pG2 |
| Background: | This gene encodes a transmembrane protein that contains multiple epidermal growth factor repeats that functions as a regulator of cell growth. The encoded protein is involved in the differentiation of several cell types including adipocytes. This gene is located in a region of chromosome 14 frequently showing unparental disomy, and is imprinted and expressed from the paternal allele. A single nucleotide variant in this gene is associated with child and adolescent obesity and shows polar overdominance, where heterozygotes carrying an active paternal allele express the phenotype, while mutant homozygotes are normal. |
| UniProt Protein Function: | DLK1: May have a role in neuroendocrine differentiation. Monomer. Found within the stromal cells in close contact to the vascular structure of placental villi, yolk sac, fetal liver, adrenal cortex and pancreas and in the beta cells of the islets of Langerhans in the adult pancreas. Found also in some forms of neuroendocrine lung tumor tissue. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 14q32 Cellular Component: extracellular space Biological Process: negative regulation of Notch signaling pathway |
| NCBI Summary: | This gene encodes a transmembrane protein that contains multiple epidermal growth factor repeats that functions as a regulator of cell growth. The encoded protein is involved in the differentiation of several cell types including adipocytes. This gene is located in a region of chromosome 14 frequently showing unparental disomy, and is imprinted and expressed from the paternal allele. A single nucleotide variant in this gene is associated with child and adolescent obesity and shows polar overdominance, where heterozygotes carrying an active paternal allele express the phenotype, while mutant homozygotes are normal. [provided by RefSeq, Nov 2015] |
| UniProt Code: | P80370 |
| NCBI GenInfo Identifier: | 296439371 |
| NCBI Gene ID: | 8788 |
| NCBI Accession: | P80370.3 |
| UniProt Secondary Accession: | P80370,P15803, Q96DW5, |
| UniProt Related Accession: | P80370 |
| Molecular Weight: | 33,067 Da |
| NCBI Full Name: | Protein delta homolog 1 |
| NCBI Synonym Full Names: | delta like non-canonical Notch ligand 1 |
| NCBI Official Symbol: | DLK1 |
| NCBI Official Synonym Symbols: | DLK; FA1; ZOG; pG2; DLK-1; PREF1; Delta1; Pref-1 |
| NCBI Protein Information: | protein delta homolog 1 |
| UniProt Protein Name: | Protein delta homolog 1 |
| UniProt Synonym Protein Names: | pG2 |
| Protein Family: | Protein |
| UniProt Gene Name: | DLK1 |
| UniProt Entry Name: | DLK1_HUMAN |
 | Western blot analysis of extracts of Mouse heart, using DLK1 Rabbit pAb (CAB6578) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 180s. |
 | Immunohistochemistry of paraffin-embedded mouse stomach using DLK1 antibody (CAB6578) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human liver damage using DLK1 antibody (CAB6578) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using DLK1 antibody (CAB6578) at dilution of 1:100 (40x lens). |
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