Cell Death Antibodies 2
Anti-DIDO1 Antibody (CAB6453)
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- SKU:
- CAB6453
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-DIDO1 Antibody |
| Antibody SKU: | CAB6453 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human DIDO1 (NP_071388.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:20 - 1:50 |
| Reactivity: | Human |
| Positive Samples: | HT-29, MCF7, HepG2, BT-474 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human DIDO1 (NP_071388.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MDDK GDPS NEEA PKAI KPTS KEFR KTWG FRRT TIAK REGA GDAE ADPL EPPP PQQQ LGLS LRRS GRQP KRTE RVEQ FLTI ARRR GRRS MPVS LEDS GEPT SCPA TDAE TASE GSVE SASE TRSG PQSA STAV KERP ASSE KVKG GDDH DDTS DSDS DGLT LKEL QNRL RRKR EQEP TERP LKGI QSRL RKKR REEG PAET VGSE ASDT VEGV LPSK QEPE NDQG VVSQ AGKD DRES KLEG KAAQ DIKD EEPG DLGR PKPE CEGY DPNA LYCI CRQP HNNR FMIC CDRC EEWF HGDC VGIS |
| Gene ID: | 11083 |
| Uniprot: | Q9BTC0 |
| Cellular Location: | Cytoplasm, Nucleus, cytoskeleton, spindle |
| Calculated MW: | 59kDa/61kDa/129kDa/243kDa |
| Observed MW: | 76kDa/244kDa |
| Synonyms: | DIDO1, BYE1, C20orf158, DATF-1, DATF1, DIDO2, DIDO3, DIO-1, DIO1, dJ885L7.8 |
| Background: | Apoptosis, a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central importance for development and homeostasis in metazoan animals. In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. This gene is similar to the mouse gene and therefore is thought to be involved in apoptosis. Alternatively spliced transcripts have been found for this gene, encoding multiple isoforms. |
| UniProt Protein Function: | DATF1: Putative transcription factor, weakly pro-apoptotic when overexpressed. Tumor suppressor. Ubiquitous. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription factor Chromosomal Location of Human Ortholog: 20q13.33 Cellular Component: cytoplasm; spindle; nucleus Molecular Function:zinc ion binding Biological Process: transcription, DNA-dependent |
| NCBI Summary: | Apoptosis, a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central importance for development and homeostasis in metazoan animals. In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. This gene is similar to the mouse gene and therefore is thought to be involved in apoptosis. Alternatively spliced transcripts have been found for this gene, encoding multiple isoforms. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9BTC0 |
| NCBI GenInfo Identifier: | 116241332 |
| NCBI Gene ID: | 11083 |
| NCBI Accession: | Q9BTC0.5 |
| UniProt Secondary Accession: | Q9BTC0,O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q4VXV8 Q4VXV9, Q96D72, A8MY65, B9EH82, E1P5I1, |
| UniProt Related Accession: | Q9BTC0 |
| Molecular Weight: | 2240 |
| NCBI Full Name: | Death-inducer obliterator 1 |
| NCBI Synonym Full Names: | death inducer-obliterator 1 |
| NCBI Official Symbol: | DIDO1 |
| NCBI Official Synonym Symbols: | BYE1; DIO1; DATF1; DIDO2; DIDO3; DIO-1; DATF-1; C20orf158; dJ885L7.8 |
| NCBI Protein Information: | death-inducer obliterator 1; death-associated transcription factor 1 |
| UniProt Protein Name: | Death-inducer obliterator 1 |
| UniProt Synonym Protein Names: | Death-associated transcription factor 1; DATF-1 |
| Protein Family: | Death-inducer obliterator |
| UniProt Gene Name: | DIDO1 |
| UniProt Entry Name: | DIDO1_HUMAN |
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