Epigenetics & Nuclear Signaling Antibodies 2
Anti-DICER1 Antibody (CAB15799)
- SKU:
- CAB15799
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-DICER1 Antibody |
| Antibody SKU: | CAB15799 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 350-450 of human DICER1 (NP_001258211.1). |
| Application: | IF |
| Recommended Dilution: | IF 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 350-450 of human DICER1 (NP_001258211.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TFLR KIHA LCEE HFSP ASLD LKFV TPKV IKLL EILR KYKP YERQ QFES VEWY NNRN QDNY VSWS DSED DDED EEIE EKEK PETN FPSP FTNI LCGI IFVE R |
| Gene ID: | 23405 |
| Uniprot: | Q9UPY3 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 92kDa/208kDa/218kDa |
| Observed MW: |
| Synonyms: | DICER1, DCR1, Dicer, Dicer1e, HERNA, K12H4.8-LIKE, MNG1, RMSE2 |
| Background: | This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | DICER1: a cytoplasmic type-III RNase that plays a central role in RNA interference (RNAi) pathways to produce the active small RNAs that represses gene expression. Possesses a DEAD box RNA helicase motif in its amino terminus and a dsRNA-binding motif in the carboxy terminus. Dicer, along with Ago2 andTRBP, are the main components of the RNA-induced silencing complex (RISC). Fragile X syndrome repeats form RNA hairpins that are cut by Dicer but do not activate the interferon-inducible protein kinase, PKR. Four alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Helicase; Cell development/differentiation; Ribonuclease; RNA-binding; EC 3.1.26.3; RNA processing Chromosomal Location of Human Ortholog: 14q32.13 Cellular Component: growth cone; axon; cytoplasm; dendrite; ER-Golgi intermediate compartment; nucleus; cytosol Molecular Function:endoribonuclease activity; protein binding; miRNA binding; ribonuclease III activity; metal ion binding; double-stranded RNA binding; deoxyribonuclease I activity; helicase activity; ATP binding Biological Process: zygote asymmetric cell division; regulation of neuron differentiation; regulation of cell cycle; regulation of oligodendrocyte differentiation; miRNA-mediated gene silencing, miRNA loading onto RISC; negative regulation of transcription from RNA polymerase II promoter; embryonic hindlimb morphogenesis; olfactory bulb interneuron differentiation; post-embryonic development; cardiac muscle cell development; pre-microRNA processing; angiogenesis; DNA fragmentation during apoptosis; defense response to virus; regulation of viral genome replication; spleen development; positive regulation of myelination; positive regulation of Schwann cell differentiation; hair follicle morphogenesis; inner ear receptor cell development; mRNA stabilization; RNA interference, targeting of mRNA for destruction; multicellular organism growth; stem cell maintenance; RNA interference, conversion of ds siRNA to ss siRNA; spindle assembly; spinal cord motor neuron differentiation; miRNA-mediated gene silencing, production of miRNAs; myelin formation in the peripheral nervous system; branching morphogenesis of a tube; cartilage development; gene expression; nerve development; cerebral cortex development; RNA interference, production of siRNA; reproductive structure development; neurite morphogenesis; lung development; myoblast cell differentiation involved in skeletal muscle regeneration Disease: Pleuropulmonary Blastoma; Goiter, Multinodular 1, With Or Without Sertoli-leydig Cell Tumors; Rhabdomyosarcoma, Embryonal, 2 |
| NCBI Summary: | This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010] |
| UniProt Code: | Q9UPY3 |
| NCBI GenInfo Identifier: | 257051056 |
| NCBI Gene ID: | 23405 |
| NCBI Accession: | Q9UPY3.3 |
| UniProt Secondary Accession: | Q9UPY3,O95943, Q9UQ02, A7E2D3, B3KRG4, E0AD28, |
| UniProt Related Accession: | Q9UPY3 |
| Molecular Weight: | 1922 |
| NCBI Full Name: | Endoribonuclease Dicer |
| NCBI Synonym Full Names: | dicer 1, ribonuclease type III |
| NCBI Official Symbol: | DICER1 |
| NCBI Official Synonym Symbols: | DCR1; MNG1; Dicer; HERNA; RMSE2; Dicer1e; K12H4.8-LIKE |
| NCBI Protein Information: | endoribonuclease Dicer; helicase MOI; Dicer1, Dcr-1 homolog; helicase with RNAse motif; dicer 1, double-stranded RNA-specific endoribonuclease |
| UniProt Protein Name: | Endoribonuclease Dicer |
| UniProt Synonym Protein Names: | Helicase with RNase motif; Helicase MOI |
| Protein Family: | Endoribonuclease |
| UniProt Gene Name: | DICER1 |
| UniProt Entry Name: | DICER_HUMAN |
 | Immunofluorescence analysis of U2OS cells using DICER1 antibody (CAB15799) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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