Cell Biology Antibodies 14

Anti-DHX9 Antibody (CAB17955)

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SKU:
CAB17955
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-DHX9 Antibody
Antibody SKU:CAB17955
Antibody Size:20uL, 50uL, 100uL
Application:WB IF IP
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human DHX9
Application:WB IF IP
Recommended Dilution:WB 1:1000 - 1:2000 IF 1:50 - 1:200 IP 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, Mouse thymus, Mouse brain, Rat brain
Immunogen:Recombinant protein of human DHX9
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:1660
Uniprot:Q08211
Cellular Location:Cytoplasm, Nucleus, nucleolus
Calculated MW:24kDa/140kDa
Observed MW:140kDa
Anti-DHX9 Antibody (CAB17955)Western blot - DHX9 Rabbit pAb (CAB17955)
Synonyms:DHX9, DDX9, LKP, NDH2, NDHII, RHA
Background:This gene encodes a member of the DEAH-containing family of RNA helicases. The encoded protein is an enzyme that catalyzes the ATP-dependent unwinding of double-stranded RNA and DNA-RNA complexes. This protein localizes to both the nucleus and the cytoplasm and functions as a transcriptional regulator. This protein may also be involved in the expression and nuclear export of retroviral RNAs. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 11 and 13.
UniProt Protein Function:DDX9: a helicase that unwinds double-stranded DNA and RNA in a 3' to 5' direction. Interacts with the RNA-induced silencing complex (RISC) in human cells and functions in RISC loading. Generates multiple secondary structures that influence RNA-binding proteins. Has a dsRNA binding motif at the N-terminus, RGG-box at the carboxyl terminus, and a bidirectional nuclear transport domain of 110 amino acids at the carboxyl terminus. May play a role in X-linked gene expression.
UniProt Protein Details:

Protein type:Nuclear receptor co-regulator; Spliceosome; Nucleolus; Helicase; RNA splicing; EC 3.6.4.13; RNA-binding; RNA processing

Chromosomal Location of Human Ortholog: 1q25

Cellular Component: nucleoplasm; centrosome; membrane; cytoplasm; nucleolus; nucleus; ribonucleoprotein complex; cytosol

Molecular Function:ATP-dependent DNA helicase activity; protein binding; DNA binding; ATP-dependent RNA helicase activity; ATP binding; RNA helicase activity

Biological Process: osteoblast differentiation; circadian rhythm; RNA processing; nuclear mRNA splicing, via spliceosome; RNA splicing; positive regulation of interferon type I production; innate immune response; gene expression; DNA duplex unwinding

NCBI Summary:This gene encodes a member of the DEAH-containing family of RNA helicases. The encoded protein is an enzyme that catalyzes the ATP-dependent unwinding of double-stranded RNA and DNA-RNA complexes. This protein localizes to both the nucleus and the cytoplasm and functions as a transcriptional regulator. This protein may also be involved in the expression and nuclear export of retroviral RNAs. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 11 and 13.[provided by RefSeq, Feb 2010]
UniProt Code:Q08211
NCBI GenInfo Identifier:116241330
NCBI Gene ID:1660
NCBI Accession:Q08211.4
UniProt Related Accession:Q08211
Molecular Weight:141kDa
NCBI Full Name:ATP-dependent RNA helicase A
NCBI Synonym Full Names:DExH-box helicase 9
NCBI Official Symbol:DHX9  
NCBI Official Synonym Symbols:LKP; RHA; DDX9; NDH2; NDHII  
NCBI Protein Information:ATP-dependent RNA helicase A
UniProt Protein Name:ATP-dependent RNA helicase A
UniProt Synonym Protein Names:DEAH box protein 9; Leukophysin; LKP; Nuclear DNA helicase II; NDH II
UniProt Gene Name:DHX9  
UniProt Entry Name:DHX9_HUMAN
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