Cell Biology Antibodies 10

Anti-DHDH Antibody (CAB6577)

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SKU:
CAB6577
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-DHDH Antibody
Antibody SKU:CAB6577
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-334 of human DHDH (NP_055290.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse liver, Mouse skin, Mouse lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-334 of human DHDH (NP_055290.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MALR WGIV SVGL ISSD FTAV LQTL PRSE HQVV AVAA RDLS RAKE FAQK HDIP KAYG SYEE LAKD PSVE VAYI GTQH PQHK AAVM LCLA AGKA VLCE KPTG VNAA EVRE MVAE ARSR ALFL MEAI WTRF FPAS EALR SVLA QGTL GDLR VARA EFGK NLIH VPRA VDRA QAGG ALLD IGIY CVQF TSMV FGGQ KPEK ISVV GRRH ETGV DDTV TVLL QYPG EVHG SFTC SITV QLSN TASV SGTK GMVQ LLNP CWCP TELV VKGE HKEF PLPP VPKD CNFD NGAG MSYE AKHV WECL RKGM KESP VIPL SESE LLAD ILEE VRKA IGVT FPQD KR
Gene ID:27294
Uniprot:Q9UQ10
Cellular Location:
Calculated MW:36kDa
Observed MW:36kDa
Synonyms:DHDH, 2DD, HUM2DD
Background:This gene encodes an enzyme that belongs to the family of dihydrodiol dehydrogenases, which exist in multiple forms in mammalian tissues and are involved in the metabolism of xenobiotics and sugars. These enzymes catalyze the NADP1-linked oxidation of transdihydrodiols of aromatic hydrocarbons to corresponding catechols. This enzyme is a dimeric dihydrodiol dehydrogenase, and it differs from monomeric dihydrodiol dehydrogenases in its high substrate specificity for trans-dihydrodiols of aromatic hydrocarbons in the oxidative direction.
UniProt Protein Function:DHDH: an enzyme that belongs to the family of dihydrodiol dehydrogenases, which exist in multiple forms in mammalian tissues and are involved in the metabolism of xenobiotics and sugars. These enzymes catalyze the NADP1-linked oxidation of transdihydrodiols of aromatic hydrocarbons to corresponding catechols. This enzyme is a dimeric dihydrodiol dehydrogenase, and it differs from monomeric dihydrodiol dehydrogenases in its high substrate specificity for trans-dihydrodiols of aromatic hydrocarbons in the oxidative direction. [provided by RefSeq, Jul 2008]
UniProt Protein Details:

Protein type:EC 1.3.1.20; EC 1.1.1.179; Xenobiotic Metabolism - metabolism by cytochrome P450; Oxidoreductase

Chromosomal Location of Human Ortholog: 19q13.3

Molecular Function:NAD(P) transhydrogenase activity; electron carrier activity; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity; D-xylose 1-dehydrogenase (NADP+) activity

Biological Process: carbohydrate metabolic process; D-xylose catabolic process

NCBI Summary:This gene encodes an enzyme that belongs to the family of dihydrodiol dehydrogenases, which exist in multiple forms in mammalian tissues and are involved in the metabolism of xenobiotics and sugars. These enzymes catalyze the NADP1-linked oxidation of transdihydrodiols of aromatic hydrocarbons to corresponding catechols. This enzyme is a dimeric dihydrodiol dehydrogenase, and it differs from monomeric dihydrodiol dehydrogenases in its high substrate specificity for trans-dihydrodiols of aromatic hydrocarbons in the oxidative direction. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UQ10
NCBI GenInfo Identifier:74735193
NCBI Gene ID:27294
NCBI Accession:Q9UQ10.1
UniProt Related Accession:Q9UQ10
Molecular Weight:334
NCBI Full Name:Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
NCBI Synonym Full Names:dihydrodiol dehydrogenase (dimeric)
NCBI Official Symbol:DHDH  
NCBI Official Synonym Symbols:2DD; HUM2DD  
NCBI Protein Information:trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; D-xylose 1-dehydrogenase; 3-deoxyglucosone reductase; D-xylose-NADP dehydrogenase
UniProt Protein Name:Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
UniProt Synonym Protein Names:D-xylose 1-dehydrogenase; D-xylose-NADP dehydrogenase (EC:1.1.1.179); Dimeric dihydrodiol dehydrogenase; Hum2DD
Protein Family:Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
UniProt Gene Name:DHDH  
UniProt Entry Name:DHDH_HUMAN
Anti-DHDH Antibody (CAB6577)Western blot analysis of extracts of various cell lines, using DHDH Antibody (CAB6577) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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