UniProt Protein Function: | DHDH: an enzyme that belongs to the family of dihydrodiol dehydrogenases, which exist in multiple forms in mammalian tissues and are involved in the metabolism of xenobiotics and sugars. These enzymes catalyze the NADP1-linked oxidation of transdihydrodiols of aromatic hydrocarbons to corresponding catechols. This enzyme is a dimeric dihydrodiol dehydrogenase, and it differs from monomeric dihydrodiol dehydrogenases in its high substrate specificity for trans-dihydrodiols of aromatic hydrocarbons in the oxidative direction. [provided by RefSeq, Jul 2008] |
UniProt Protein Details: | Protein type:EC 1.3.1.20; EC 1.1.1.179; Xenobiotic Metabolism - metabolism by cytochrome P450; Oxidoreductase Chromosomal Location of Human Ortholog: 19q13.3 Molecular Function:NAD(P) transhydrogenase activity; electron carrier activity; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity; D-xylose 1-dehydrogenase (NADP+) activity Biological Process: carbohydrate metabolic process; D-xylose catabolic process |
NCBI Summary: | This gene encodes an enzyme that belongs to the family of dihydrodiol dehydrogenases, which exist in multiple forms in mammalian tissues and are involved in the metabolism of xenobiotics and sugars. These enzymes catalyze the NADP1-linked oxidation of transdihydrodiols of aromatic hydrocarbons to corresponding catechols. This enzyme is a dimeric dihydrodiol dehydrogenase, and it differs from monomeric dihydrodiol dehydrogenases in its high substrate specificity for trans-dihydrodiols of aromatic hydrocarbons in the oxidative direction. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9UQ10 |
NCBI GenInfo Identifier: | 74735193 |
NCBI Gene ID: | 27294 |
NCBI Accession: | Q9UQ10.1 |
UniProt Related Accession: | Q9UQ10 |
Molecular Weight: | 334 |
NCBI Full Name: | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase |
NCBI Synonym Full Names: | dihydrodiol dehydrogenase (dimeric) |
NCBI Official Symbol: | DHDH |
NCBI Official Synonym Symbols: | 2DD; HUM2DD |
NCBI Protein Information: | trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; D-xylose 1-dehydrogenase; 3-deoxyglucosone reductase; D-xylose-NADP dehydrogenase |
UniProt Protein Name: | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase |
UniProt Synonym Protein Names: | D-xylose 1-dehydrogenase; D-xylose-NADP dehydrogenase (EC:1.1.1.179); Dimeric dihydrodiol dehydrogenase; Hum2DD |
Protein Family: | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase |
UniProt Gene Name: | DHDH |
UniProt Entry Name: | DHDH_HUMAN |