Cell Biology Antibodies 14
Anti-DGKG Antibody (CAB16827)
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- SKU:
- CAB16827
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-DGKG Antibody |
| Antibody SKU: | CAB16827 |
| Antibody Size: | 20uL, 50 uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human DGKG (NP_001074214.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human DGKG (NP_001074214.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MGEE RWVS LTPE EFDQ LQKY SEYS SKKI KDAL TEFN EGGS LKQY DPHE PISY DVFK LFMR AYLE VDLP QPLS THLF LAFS QKPR HETS DHPT EGAS NSEA NSAD TNIQ NADN ATKA DEAC APDT ESNM AEKQ APAE DQVA ATPL EPPV PRSS SSES PVVY LKDV VCYL SLLE TGRP QDKL EFMF RLYD SDEN GLLD QAEM DCIV NQML HIAQ YLEW DPTE LRPI LKEM LQGM DYDR DGFV SLQE WVHG GM |
| Gene ID: | 1608 |
| Uniprot: | P49619 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | DGKG, DAGK3, DGK-GAMMA |
| Background: | This gene encodes an enzyme that is a member of the type I subfamily of diacylglycerol kinases, which are involved in lipid metabolism. These enzymes generate phosphatidic acid by catalyzing the phosphorylation of diacylglycerol, a fundamental lipid second messenger that activates numerous proteins, including protein kinase C isoforms, Ras guanyl nucleotide-releasing proteins and some transient receptor potential channels. Diacylglycerol kinase gamma has been implicated in cell cycle regulation and in the negative regulation of macrophage differentiation in leukemia cells. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | DGKG: Reverses the normal flow of glycerolipid biosynthesis by phosphorylating diacylglycerol back to phosphatidic acid. Belongs to the eukaryotic diacylglycerol kinase family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 2.7.1.107; Lipid Metabolism - glycerolipid; Motility/polarity/chemotaxis; Lipid Metabolism - glycerophospholipid; Kinase, lipid Chromosomal Location of Human Ortholog: 3q27.2-q27.3 Cellular Component: cytoplasm; plasma membrane Molecular Function:ATP binding; calcium ion binding; diacylglycerol kinase activity Biological Process: blood coagulation; neuron development; phosphorylation; platelet activation; protein kinase C activation; signal transduction |
| NCBI Summary: | This gene encodes an enzyme that is a member of the type I subfamily of diacylglycerol kinases, which are involved in lipid metabolism. These enzymes generate phosphatidic acid by catalyzing the phosphorylation of diacylglycerol, a fundamental lipid second messenger that activates numerous proteins, including protein kinase C isoforms, Ras guanyl nucleotide-releasing proteins and some transient receptor potential channels. Diacylglycerol kinase gamma has been implicated in cell cycle regulation and in the negative regulation of macrophage differentiation in leukemia cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P49619 |
| NCBI GenInfo Identifier: | 124256474 |
| NCBI Gene ID: | 1608 |
| NCBI Accession: | NP_001074213.1 |
| UniProt Secondary Accession: | P49619,Q2M1H4, Q5FWG1, B2RAH4, |
| UniProt Related Accession: | P49619 |
| Molecular Weight: | 44.9 kDa |
| NCBI Full Name: | diacylglycerol kinase gamma isoform 2 |
| NCBI Synonym Full Names: | diacylglycerol kinase gamma |
| NCBI Official Symbol: | DGKG |
| NCBI Official Synonym Symbols: | DAGK3; DGK-GAMMA |
| NCBI Protein Information: | diacylglycerol kinase gamma |
| UniProt Protein Name: | Diacylglycerol kinase gamma |
| UniProt Synonym Protein Names: | Diglyceride kinase gamma; DGK-gamma |
| Protein Family: | Diacylglycerol kinase |
| UniProt Gene Name: | DGKG |
| UniProt Entry Name: | DGKG_HUMAN |
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